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调整戈克曼疗法用于肯尼亚的银屑病治疗:资源有限环境下成功管理的案例研究

Adapting the Goeckerman Regimen for Psoriasis Treatment in Kenya: A Case Study of Successful Management in a Resource-Limited Setting.

作者信息

Smith Payton, Kranyak Allison, Johnson Chandler E, Haran Kathryn, Muraguri Snr Isabel, Maurer Toby, Bhutani Tina, Liao Wilson, Kiprono Samson

机构信息

Department of Dermatology, University of California at San Francisco, San Francisco, CA, USA.

Department of Dermatology, Moi Teaching and Referral Hospital, Eldoret, Kenya.

出版信息

Psoriasis (Auckl). 2024 Aug 29;14:93-100. doi: 10.2147/PTT.S481148. eCollection 2024.

Abstract

INTRODUCTION

Goeckerman therapy, which combines ultraviolet B (UVB) light with crude coal tar (CCT), remains highly effective for moderate-to-severe psoriasis. While it is rarely still used in the USA as effective biotherapeutics have become more readily available, it offers an alternative therapy in developing countries with limited access to newer medications. Moi Teaching & Referral Hospital (MTRH) in Eldoret, Kenya, in collaboration with UCSF, developed a modified Goeckerman regimen suitable for local healthcare needs, condensing the treatment into an intensive two-week program.

CASE REPORT

A 55-year-old female with erythrodermic psoriasis traveled 350 kilometers to MTRH. After the diagnosis was confirmed, she underwent a nine-day inpatient treatment with narrow-band UVB phototherapy and topical medications under occlusion as a modified Goeckerman regimen.

RESPONSE TO TREATMENT

Significant improvement was observed within three days, with full recovery in ten days. Follow-up one month later showed no active lesions, and her psoriasis remained controlled for four months with topical treatments.

CONCLUSION

The modified Goeckerman regimen at MTRH, in collaboration with UCSF, effectively treated severe psoriasis in a challenging healthcare context. This case highlights the potential for adapting established treatments to improve patient outcomes in developing countries with limited access to systemic therapies.

摘要

引言

Goeckerman疗法将紫外线B(UVB)光与粗煤焦油(CCT)相结合,对中重度银屑病仍然非常有效。尽管在美国由于更易获得有效的生物疗法而很少使用,但它为难以获得新药物的发展中国家提供了一种替代疗法。肯尼亚埃尔多雷特的莫伊教学与转诊医院(MTRH)与加州大学旧金山分校合作,制定了一种适合当地医疗需求的改良Goeckerman方案,将治疗浓缩为一个为期两周的强化疗程。

病例报告

一名患有红皮病型银屑病的55岁女性跋涉350公里来到MTRH。确诊后,她接受了为期九天的住院治疗,采用窄带UVB光疗和局部药物封包治疗,作为改良的Goeckerman方案。

治疗反应

三天内观察到显著改善,十天内完全康复。一个月后的随访显示没有活动性病变,她的银屑病通过局部治疗持续控制了四个月。

结论

MTRH与加州大学旧金山分校合作的改良Goeckerman方案在具有挑战性的医疗环境中有效治疗了重度银屑病。该病例突出了在难以获得全身治疗的发展中国家,调整现有治疗方法以改善患者预后的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af0/11368149/bb272ce6f3e3/PTT-14-93-g0001.jpg

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