蛋白质合成抑制剂嘌呤霉素和吐根碱可抑制骨骼肌释放前列腺素E2。
Inhibitors of protein synthesis, puromycin and emetine, inhibit prostaglandin E2 release by skeletal muscle.
作者信息
Turinsky J
出版信息
Biochim Biophys Acta. 1985 May 29;840(1):134-6.
PMID:3922426
Abstract
Addition of 1 microM puromycin or 1 microM emetine to rat soleus muscle in vitro decreases muscle prostaglandin E2 release by 51-77%. This inhibition appears to be caused by decreased availability of endogenous arachidonic acid for prostaglandin E2 synthesis, because neither puromycin nor emetine inhibits muscle prostaglandin E2 production from arachidonic acid added into the incubation medium.
摘要
在体外向大鼠比目鱼肌中添加1微摩尔的嘌呤霉素或1微摩尔的依米丁，可使肌肉前列腺素E2的释放减少51%-77%。这种抑制作用似乎是由于内源性花生四烯酸用于前列腺素E2合成的可用性降低所致，因为嘌呤霉素和依米丁均不抑制向孵育培养基中添加的花生四烯酸产生肌肉前列腺素E2。
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