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探索未知领域：代谢物谱分析揭示了……的抗癌特性。 （原文此处不完整）

Exploring the uncharted seas: Metabolite profiling unleashes the anticancer properties of .

作者信息

Das Bornita, Prusty Asharani, Dutta Subhajeet, Maulik Aditi, Dahat Yogita, Kumar Deepak, Tripathy Sucheta

机构信息

Computational Genomics Lab, Structural Biology and Bioinformatics Division, CSIR Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata, 700032, India.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.

出版信息

Heliyon. 2024 Aug 10;10(16):e36048. doi: 10.1016/j.heliyon.2024.e36048. eCollection 2024 Aug 30.

DOI:10.1016/j.heliyon.2024.e36048
PMID:39224332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11367535/
Abstract

Marine cyanobacteria offer a rich source of varied natural products with both chemical and biological diversity. () is a filamentous non-heterocystous marine cyanobacterium from Oscillatoriaceae family. In this investigation, we have unveiled bioactive extracts from using two distinct solvent systems, revealing significant anticancer properties. Our assessment of the organic and aqueous extracts (MCE and AE) of demonstrated pronounced antiproliferative and antimetastatic effects. Notably, this study is the first to elucidate the anticancer and anti-metastatic potential of extracts in both 2D and 3D cell culture models. Both MCE and AE induced apoptosis, hindered cell proliferation, invasion, and migration in A549 non-small cell lung cancer cells, accompanied by alterations in cell morphology and cytoskeleton collapse. Moreover, MCE and AE induced spheroid disintegration in A549 cells. Transcriptomics analysis highlighted the significant involvement of Rap1 and p53 signaling pathways in mediating the observed antitumor effects. Mass spectroscopy characterization of these extracts identified 11 compounds, some known for their anticancer potential. HPLC analysis of AE revealed six peaks with UV absorption spectra resembling phycocyanin, a cyanobacterial pigment with well-known anticancer activity. Collectively, these findings underscore the anticancer potential of MCE and AE, containing bioactive metabolites with anticancer and antimetastatic properties.

摘要

海洋蓝藻细菌提供了丰富多样的天然产物来源，具有化学和生物多样性。（）是一种来自颤藻科的丝状非异形胞海洋蓝藻细菌。在本研究中，我们使用两种不同的溶剂系统揭示了（）的生物活性提取物，显示出显著的抗癌特性。我们对（）的有机提取物和水提取物（MCE和AE）的评估表明，它们具有明显的抗增殖和抗转移作用。值得注意的是，本研究首次阐明了（）提取物在二维和三维细胞培养模型中的抗癌和抗转移潜力。MCE和AE均诱导A549非小细胞肺癌细胞凋亡，阻碍细胞增殖、侵袭和迁移，同时伴有细胞形态改变和细胞骨架塌陷。此外，MCE和AE诱导A549细胞球体解体。转录组学分析突出了Rap1和p53信号通路在介导观察到的抗肿瘤作用中的重要参与。这些提取物的质谱表征鉴定出11种化合物，其中一些因其抗癌潜力而闻名。AE的HPLC分析显示出六个峰，其紫外吸收光谱类似于藻蓝蛋白，藻蓝蛋白是一种具有众所周知抗癌活性的蓝藻色素。总体而言，这些发现强调了MCE和AE的抗癌潜力，它们含有具有抗癌和抗转移特性的生物活性代谢物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/9a232f92939e/mmcfigs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/5a820af3dff8/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/721204fa290b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/75c5ae0fcc17/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/e8b8f7886bc5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/05c5fea06230/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/58f2c6c545a6/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/58ffdb3e782f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/8c9e732dbb96/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/fb7953de2f54/mmcfigs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/9a232f92939e/mmcfigs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/5a820af3dff8/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/721204fa290b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/75c5ae0fcc17/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/e8b8f7886bc5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/05c5fea06230/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/58f2c6c545a6/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/58ffdb3e782f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/8c9e732dbb96/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/fb7953de2f54/mmcfigs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e3d/11367535/9a232f92939e/mmcfigs2.jpg

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