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High sperm DNA fragmentation - finding a needle in the haystack: tips on selecting the best sperm for ICSI and ART.

作者信息

Baldi Elisabetta, Colpi Giovanni M, Huang Zhong-Wei, Balagobi Balasingam, Boitrelle Florence, Shah Rupin, Agarwal Ashok

机构信息

Department of Experimental and Clinical Medicine, University of Florence, Piazza San Marco, Firenze 4-50121, Italy.

Global Andrology Forum, Moreland Hills, OH 44022, USA.

出版信息

Asian J Androl. 2025 Mar 1;27(2):139-143. doi: 10.4103/aja202451. Epub 2024 Sep 3.

DOI:10.4103/aja202451
PMID:39224976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11949445/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9032/11949445/a84557082e22/AJA-27-139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9032/11949445/a84557082e22/AJA-27-139-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9032/11949445/a84557082e22/AJA-27-139-g001.jpg

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Severe sperm DNA fragmentation may persist for up to 3 years after cytotoxic therapy in patients affected by Hodgkin lymphoma and non-Hodgkin lymphoma.严重的精子 DNA 碎片化在霍奇金淋巴瘤和非霍奇金淋巴瘤患者接受细胞毒性治疗后可能持续长达 3 年。
Hum Reprod. 2024 Mar 1;39(3):496-503. doi: 10.1093/humrep/dead269.
2
Does Testicular Sperm Improve Intracytoplasmic Sperm Injection Outcomes for Nonazoospermic Infertile Men with Elevated Sperm DNA Fragmentation? A Systematic Review and Meta-analysis.睾丸精子是否能改善精子 DNA 碎片率升高的非梗阻性不育男性的卵胞浆内单精子注射结局?系统评价和荟萃分析。
Eur Urol Focus. 2024 May;10(3):410-420. doi: 10.1016/j.euf.2023.08.008. Epub 2023 Sep 13.
3
Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation.
癌症患者行精子冷冻保存术对精液质量及精子 DNA 碎片的影响。
Investig Clin Urol. 2023 Sep;64(5):489-494. doi: 10.4111/icu.20220402.
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Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations.男性不育症中精子DNA碎片化检测的技术方面与临床局限性:一项全球调查、现行指南及专家建议
World J Mens Health. 2024 Jan;42(1):202-215. doi: 10.5534/wjmh.230076. Epub 2023 Aug 24.
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Paternal Age Matters: Association with Sperm Criteria's- Spermatozoa DNA Integrity and Methylation Profile.父亲年龄很重要:与精子指标——精子DNA完整性和甲基化谱的关联。
J Clin Med. 2023 Jul 27;12(15):4928. doi: 10.3390/jcm12154928.
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Impact of body mass index on semen parameters and reproductive hormones among men undergoing microsurgical subinguinal varicocelectomy.体重指数对接受显微外科腹股沟下精索静脉结扎术男性精液参数和生殖激素的影响。
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The effect of sperm DNA fragmentation on in vitro fertilization outcomes of unexplained infertility.精子 DNA 碎片化对不明原因不孕的体外受精结局的影响。
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