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非梗阻性无精子症的表观遗传学

Epigenetics of nonobstructive azoospermia.

作者信息

Gunes Sezgin, Mahmutoglu Asli Metin, Hekim Neslihan

机构信息

Department of Medical Biology, Medical Faculty, Ondokuz Mayis University, Samsun 55139, Türkiye.

Department of Medical Biology, Medical Faculty, Yozgat Bozok University, Yozgat 66100, Türkiye.

出版信息

Asian J Androl. 2025 May 1;27(3):311-321. doi: 10.4103/aja202463. Epub 2024 Sep 3.

DOI:10.4103/aja202463
PMID:39225008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12112928/
Abstract

Nonobstructive azoospermia (NOA) is a severe and heterogeneous form of male factor infertility caused by dysfunction of spermatogenesis. Although various factors are well defined in the disruption of spermatogenesis, not all aspects due to the heterogeneity of the disorder have been determined yet. In this review, we focus on the recent findings and summarize the current data on epigenetic mechanisms such as DNA methylation and different metabolites produced during methylation and demethylation and various types of small noncoding RNAs involved in the pathogenesis of different groups of NOA.

摘要

非梗阻性无精子症（NOA）是一种由精子发生功能障碍引起的严重且异质性的男性因素不育症。尽管在精子发生破坏方面各种因素已明确，但由于该疾病的异质性，并非所有方面都已确定。在本综述中，我们关注近期的研究发现，并总结关于表观遗传机制的当前数据，如DNA甲基化以及甲基化和去甲基化过程中产生的不同代谢产物，以及参与不同组NOA发病机制的各种类型的小非编码RNA。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c04/12112928/961c8d2f8424/AJA-27-311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c04/12112928/22b929eeaeb4/AJA-27-311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c04/12112928/7527d9a0a420/AJA-27-311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c04/12112928/98b6e5bf0516/AJA-27-311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c04/12112928/961c8d2f8424/AJA-27-311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c04/12112928/22b929eeaeb4/AJA-27-311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c04/12112928/7527d9a0a420/AJA-27-311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c04/12112928/98b6e5bf0516/AJA-27-311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c04/12112928/961c8d2f8424/AJA-27-311-g004.jpg

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本文引用的文献

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Nat Rev Urol. 2024 Feb;21(2):67-90. doi: 10.1038/s41585-023-00837-9. Epub 2023 Dec 18.
2
Proteomic approach towards identification of seminal fluid biomarkers from individuals with severe oligozoospermia, cryptozoospermia and non-obstructive azoospermia: a pilot study.采用蛋白质组学方法从严重少精子症、隐匿性精子症和非梗阻性无精子症患者中鉴定精液生物标志物：一项初步研究。
Transl Androl Urol. 2023 Oct 31;12(10):1497-1510. doi: 10.21037/tau-23-130. Epub 2023 Oct 24.
3
Micro RNA in Semen/Urine from Non-Obstructive Azoospermia Patients as Biomarkers to Predict the Presence of Testicular Spermatozoa and Spermatogonia.
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Life (Basel). 2023 Feb 23;13(3):616. doi: 10.3390/life13030616.
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Front Endocrinol (Lausanne). 2023 Jan 17;13:1109807. doi: 10.3389/fendo.2022.1109807. eCollection 2022.
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