State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials; Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application; Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis; College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
State Key Laboratory of Radiation Medicine and Protection, School of Radiological and Interdisciplinary Sciences (RADX), Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China.
ACS Appl Mater Interfaces. 2024 Sep 11;16(36):46947-46963. doi: 10.1021/acsami.4c09963. Epub 2024 Sep 3.
Biomedical-device-associated infection (BAI) is undoubtedly a major concern and a serious challenge in modern medicine. Therefore, the development of biomedical materials that are capable of resisting or killing bacteria is of great importance. In this work, a croconaine-functionalized polymer with antifouling and near-infrared (NIR) photothermal bactericidal properties was prepared and facilely modified on polypropylene (PP) to combat medical device infections. Croconaine dye is elaborately modified as a "living" initiator, termed CR-4EBiB, for preparing amphiphilic block polymers by atom transfer radical polymerization (ATRP). In the formed polymer coating, the hydrophobic block can strongly adhere to the surface of the PP substrate, whereas the hydrophilic block is located on the outer layer by solvent-induced resistance to bacterial adhesion. Under the irradiation of an NIR laser (808 nm), the croconaine dye in the coating achieved maximum conversion of light to heat to effectively kill , , and methicillin-resistant (MRSA). This work provides a facile and promising strategy for the development of implantable antibacterial biomedical materials.
医疗器械相关感染（BAI）无疑是现代医学的一大关注点和严峻挑战。因此，开发能够抵抗或杀灭细菌的生物医学材料至关重要。在这项工作中，制备了一种具有抗污和近红外（NIR）光热杀菌性能的隐色孔雀花青功能化聚合物，并简便地修饰在聚丙烯（PP）上以对抗医疗器械感染。隐色孔雀花青染料被精心修饰为“活”引发剂，称为 CR-4EBiB，通过原子转移自由基聚合（ATRP）制备两亲嵌段聚合物。在形成的聚合物涂层中，疏水性嵌段可以强烈地附着在 PP 基底表面，而亲水性嵌段通过溶剂诱导的抗细菌附着位于外层。在 NIR 激光（808nm）照射下，涂层中的隐色孔雀花青染料实现了光到热的最大转化率，有效地杀死 、 和耐甲氧西林金黄色葡萄球菌（MRSA）。这项工作为开发可植入抗菌生物医学材料提供了一种简便而有前景的策略。
