State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of Biomedical Materials , Beijing University of Chemical Technology , Beijing 100029 , China.
Department of Dental Implant Center, Beijing Stomatological Hospital, School of Stomatology , Capital Medical University , Beijing 100050 , China.
ACS Nano. 2020 Feb 25;14(2):2265-2275. doi: 10.1021/acsnano.9b09282. Epub 2020 Feb 5.
Biomedical device-associated infection (BAI) is a great challenge in modern clinical medicine. Therefore, developing efficient antibacterial materials is significantly important and meaningful for the improvement of medical treatment and people's health. In the present work, we developed a strategy of surface functionalization for multifunctional antibacterial applications. A functionalized polyurethane (PU, a widely used biomedical material for hernia repairing) surface (PU-Au-PEG) with inherent antifouling and photothermal bactericidal properties was readily prepared based on a near-infrared (NIR)-responsive organic/inorganic hybrid coating which consists of gold nanorods (Au NRs) and polyethylene glycol (PEG). The PU-Au-PEG showed a high efficiency to resist adhesion of bacteria and exhibited effective photothermal bactericidal properties under 808 nm NIR irradiation, especially against multidrug-resistant bacteria. Furthermore, the PU-Au-PEG could inhibit biofilm formation long term. The biocompatibility of PU-Au-PEG was also proved by cytotoxicity and hemolysis tests. The photothermal antibacterial properties were first verified by a subcutaneous implantation animal model. Then, the anti-infection performance in a clinical scenario was studied with an infected hernia model. The results of animal experiment studies demonstrated excellent anti-infection performances of PU-Au-PEG. The present work provides a facile and promising approach to develop multifunctional biomedical devices.
医疗器械相关感染（BAI）是现代临床医学面临的重大挑战。因此，开发高效的抗菌材料对于提高医疗水平和人们的健康具有重要意义。在本工作中，我们开发了一种用于多功能抗菌应用的表面功能化策略。基于由金纳米棒（Au NRs）和聚乙二醇（PEG）组成的近红外（NIR）响应型有机/无机杂化涂层，制备了具有固有抗污和光热杀菌性能的功能化聚氨酯（PU，一种用于疝修补的广泛使用的生物医学材料）表面（PU-Au-PEG）。PU-Au-PEG 对细菌的黏附具有高效的抑制作用，并在 808nmNIR 照射下表现出有效的光热杀菌性能，尤其对多药耐药菌有效。此外，PU-Au-PEG 可以长期抑制生物膜的形成。通过细胞毒性和溶血试验证明了 PU-Au-PEG 的生物相容性。光热抗菌性能首先通过皮下植入动物模型进行了验证。然后，通过感染疝模型研究了临床场景中的抗感染性能。动物实验研究结果表明，PU-Au-PEG 具有优异的抗感染性能。本工作为开发多功能生物医学器件提供了一种简便、有前景的方法。
