College of Medicine, Southwest Jiaotong University, Chengdu 610003, China.
The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, China.
Biomater Sci. 2024 Oct 8;12(20):5134-5149. doi: 10.1039/d4bm00794h.
Microneedles have recently emerged as a groundbreaking technology in the field of biomedical detection. Notable for their small size and ability to penetrate the superficial layers of the skin, microneedles provide an innovative platform for localized and real-time detection. This review explores the integration of various detection methods with microneedle technology, focusing particularly on its applications in biomedical contexts. First, the common detection methods, such as colorimetric, electrochemical, spectrometric, and fluorescence methods, combined with microneedle technology, are summarized. Then we showcase exemplary uses of microneedle technology in biomedical detection, including the monitoring of blood glucose levels, evaluating infection statuses in skin wounds, facilitating point-of-care testing, and identifying biomarkers in the interstitial fluid of the skin. Microneedle-based detection, with its painless, minimally invasive, and biocompatible approach, holds significant promise for enhancing biological assays. Finally, the review concludes by assessing the future potential and challenges of microneedle detection technology, underscoring its transformative capacity to advance personalized medicine and revolutionize healthcare practices.
微针技术作为生物医学检测领域的一项突破性技术，近年来崭露头角。微针因其体积小巧、能够穿透皮肤的浅层而备受关注，为局部实时检测提供了创新平台。本综述探讨了各种检测方法与微针技术的融合，特别关注其在生物医学领域的应用。首先，总结了常见的检测方法，如比色法、电化学法、光谱法和荧光法，以及与微针技术的结合。然后，我们展示了微针技术在生物医学检测中的一些典型应用，包括血糖监测、皮肤伤口感染状态评估、即时检测的促进以及皮肤间质液中生物标志物的识别。基于微针的检测具有无痛、微创和生物相容性的特点，有望增强生物分析。最后，通过评估微针检测技术的未来潜力和挑战，本文总结了其变革性能力，可推动个性化医疗并革新医疗实践。
