Kim Gwangmook, Ahn Hyunah, Chaj Ulloa Joshua, Gao Wei
Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA USA.
Med X. 2024;2(1):15. doi: 10.1007/s44258-024-00028-0. Epub 2024 Oct 1.
The rapid advancement in personalized healthcare has driven the development of wearable biomedical devices for real-time biomarker monitoring and diagnosis. Traditional invasive blood-based diagnostics are painful and limited to sporadic health snapshots. To address these limitations, microneedle-based sensing platforms have emerged, utilizing interstitial fluid (ISF) as an alternative biofluid for continuous health monitoring in a minimally invasive and painless manner. This review aims to provide a comprehensive overview of microneedle sensor technology, covering microneedle design, fabrication methods, and sensing strategy. Additionally, it explores the integration of monitoring electronics for continuous on-body monitoring. Representative applications of microneedle sensing platforms for both monitoring and therapeutic purposes are introduced, highlighting their potential to revolutionize personalized healthcare. Finally, the review discusses the remaining challenges and future prospects of microneedle technology.
个性化医疗的迅速发展推动了可穿戴生物医学设备的开发，用于实时生物标志物监测和诊断。传统的基于血液的侵入性诊断方法既痛苦又局限于零散的健康快照。为了解决这些局限性，基于微针的传感平台应运而生，利用间质液（ISF）作为替代生物流体，以微创和无痛的方式进行连续健康监测。本综述旨在全面概述微针传感器技术，涵盖微针设计、制造方法和传感策略。此外，还探讨了用于连续身体监测的监测电子设备的集成。介绍了微针传感平台在监测和治疗方面的代表性应用，突出了它们在变革个性化医疗方面的潜力。最后，本综述讨论了微针技术仍然存在的挑战和未来前景。
