College of Medicine, Wuhan University of Science and Technology, Wuhan, China.
Department of Cardiology, Institute of Cardiovascular Diseases, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
J Clin Hypertens (Greenwich). 2024 Nov;26(11):1228-1236. doi: 10.1111/jch.14895. Epub 2024 Sep 3.
This study was conducted to investigate the association between alcohol consumption in adolescence and the risk of hypertension or prehypertension development in early adulthood. This cohort study included adolescent participants aged 12-18 years from the 2000-2011 China Health and Nutrition Survey. Cox proportional risk regression models were used to analyze the associations of the frequency of alcohol consumption, alcohol intake, and type of alcohol with the risk of developing hypertension or prehypertension. Restricted cubic spline analysis was used to assess the dose-response relationships for alcohol intake and their hazard ratios (HRs). A total of 1556 participants were included in the final analysis. Among the overall population, 448 (30.81%) and 35 (34.31%) participants developed hypertension or prehypertension, respectively. Compared with no alcohol consumption, alcohol consumption ≥ 2 times/week and consumption of ≥2 types of alcohol were associated with an increased risk of hypertension and prehypertension, with HRs of 1.97 (95% confidence interval [CI] 1.17-3.34; p = 0.011) and 1.77 (95% CI 1.01-3.09; p = 0.046), respectively. Alcohol intake of > 96 mL/week was associated with an increased risk of hypertension and prehypertension, with HRs of 2.09 (95% CI 1.12-3.90; p = 0.020) and 2.07 (95% CI 1.11-3.84; p = 0.021), respectively. The restricted cubic spline analysis showed that the risk of developing high blood pressure or prehypertension tends to increase with increasing alcohol consumption. Heavy alcohol consumption in adolescence increased the risk of developing hypertension and prehypertension in early adulthood.
本研究旨在探讨青少年时期饮酒与成年早期高血压或高血压前期发展风险之间的关联。这项队列研究纳入了来自 2000-2011 年中国健康与营养调查的 12-18 岁青少年参与者。使用 Cox 比例风险回归模型分析了饮酒频率、饮酒量和酒的类型与高血压或高血压前期发展风险之间的关联。采用限制性立方样条分析评估了饮酒量与危险比（HR）之间的剂量-反应关系。共有 1556 名参与者纳入最终分析。在总体人群中，分别有 448（30.81%）和 35（34.31%）名参与者发展为高血压或高血压前期。与不饮酒相比，每周饮酒≥2 次和饮酒≥2 种类型与高血压和高血压前期的风险增加相关，HR 分别为 1.97（95%置信区间 [CI] 1.17-3.34；p=0.011）和 1.77（95% CI 1.01-3.09；p=0.046）。每周饮酒量>96 毫升与高血压和高血压前期的风险增加相关，HR 分别为 2.09（95% CI 1.12-3.90；p=0.020）和 2.07（95% CI 1.11-3.84；p=0.021）。限制性立方样条分析表明，随着饮酒量的增加，发生高血压或高血压前期的风险呈上升趋势。青少年时期大量饮酒会增加成年早期患高血压和高血压前期的风险。
