Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, China.
Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou City, China.
Hypertens Res. 2018 Jan;41(1):66-74. doi: 10.1038/hr.2017.86. Epub 2017 Oct 5.
Hypertension and prehypertension may have important roles in the etiology of cardiovascular disease. However, the risk factors of hypertension and prehypertension have not been thoroughly elucidated to date. This study intended to explore the relative effects between reproductive history and the prevalence of hypertension and prehypertension. A population-based cross-sectional survey of postmenopausal women (n=6252), aged 41-93 years, was conducted from August 2013 to August 2015. All subjects, selected by the multistage random sampling method in Henan province, were categorized as normotension, prehypertension and hypertension according to blood pressure (BP) levels. Ordinal logistic regression models were used to estimate the risks of prehypertension and hypertension with three categories of BP as dependent variables. Hypertension was associated with a positive history of induced abortion (adjusted odds ratio (OR)=1.190, 95% confidence interval (CI): 1.020, 1.388), but there was no association between hypertension and a positive history of spontaneous abortion (adjusted OR=1.126, 95% CI: 0.973, 1.303) after adjusting for age, alcohol consumption, education status, smoking, body mass index, physical activity and occupation. Compared with women with one or no children, those with two or three children were at a lower risk of hypertension (adjusted OR=0.605, 95% CI: 0.434, 0.845). In addition, individuals with an age of menopause between 46 and 51 years may have a decreased risk of both prehypertension and hypertension, especially in terms of systolic BP. In conclusion, a positive history of induced abortion may be a predictive risk factor for hypertension and prehypertension. However, a menopausal age of 46-51 years or having two children may be protective factors against hypertension and prehypertension.
高血压和高血压前期可能在心血管疾病的病因中发挥重要作用。然而，迄今为止，高血压和高血压前期的危险因素尚未得到彻底阐明。本研究旨在探讨生殖史与高血压和高血压前期患病率之间的相对影响。2013 年 8 月至 2015 年 8 月，采用多阶段随机抽样方法，对河南省 6252 名年龄在 41-93 岁的绝经后妇女进行了一项基于人群的横断面调查。所有受试者均根据血压（BP）水平分为正常血压、高血压前期和高血压。采用有序逻辑回归模型，以 BP 三个分类为因变量，估算高血压前期和高血压的风险。高血压与人工流产史（校正比值比（OR）=1.190，95%置信区间（CI）：1.020，1.388）呈正相关，但高血压与自然流产史（校正 OR=1.126，95% CI：0.973，1.303）之间无关联，在调整年龄、饮酒、教育程度、吸烟、体重指数、体力活动和职业后。与有一个或没有孩子的女性相比，有两个或三个孩子的女性患高血压的风险较低（校正 OR=0.605，95% CI：0.434，0.845）。此外，绝经年龄在 46-51 岁之间的个体可能患高血压前期和高血压的风险降低，尤其是收缩压。总之，人工流产史可能是高血压和高血压前期的预测风险因素。然而，绝经年龄为 46-51 岁或有两个孩子可能是高血压和高血压前期的保护因素。
