Cai Jing, Ni Yu-Qing, Liu You-Shuo
Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Institute of Aging and Age-related Disease Research, Central South University, Changsha, Hunan, China.
Aging Dis. 2024 Aug 19;16(4):1793-1812. doi: 10.14336/AD.2024.0762.
Alzheimer's Disease (AD) is the most prevalent, costly, and fatal neurodegenerative disorder of this century. Two hallmark features of AD are the anomalous cleavage of amyloid precursor protein (APP), which leads to the accumulation of amyloid-beta (Aβ), and the hyperphosphorylation of tau protein. Despite extensive research efforts, the pathology and pathogenesis of AD remain elusive. Recent investigations have highlighted the close association between antisense long non-coding RNAs (AS-lncRNAs) and various biological and functional aspects of AD. However, many AS-lncRNAs implicated in AD have not yet been comprehensively compiled and discussed. This paper reviews the role of AS-lncRNAs in neurodegenerative diseases, outlines their association with AD, and offers novel insights into the potential applications of antisense RNAs in the diagnosis and treatment of AD.
阿尔茨海默病（AD）是本世纪最常见、代价高昂且致命的神经退行性疾病。AD的两个标志性特征是淀粉样前体蛋白（APP）的异常切割，这会导致β淀粉样蛋白（Aβ）的积累，以及tau蛋白的过度磷酸化。尽管进行了广泛的研究，但AD的病理学和发病机制仍然难以捉摸。最近的研究突出了反义长链非编码RNA（AS-lncRNAs）与AD的各种生物学和功能方面的密切关联。然而，许多与AD相关的AS-lncRNAs尚未得到全面的汇编和讨论。本文综述了AS-lncRNAs在神经退行性疾病中的作用，概述了它们与AD的关联，并为反义RNA在AD诊断和治疗中的潜在应用提供了新的见解。
