Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, United States.
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, United States.
J Appl Microbiol. 2024 Sep 2;135(9). doi: 10.1093/jambio/lxae210.
The aim of this work was to evaluate the efficacy of an organosilicon-based, commercially available antimicrobial formulation in the My-shield® product line against bacterial surface contamination.
The antimicrobial product was tested in vitro for its long-term persistence on surfaces and effectiveness against Staphylococcus aureus biofilms in comparison to 70% ethanol and 0.1% or 0.6% sodium hypochlorite. Field testing was also conducted over 6 weeks at a university athletic facility. In vitro studies demonstrated the log reductions achieved by the test product, 70% ethanol, and 0.1% sodium hypochlorite were 3.6, 3.1, and 3.2, respectively. The test product persisted on surfaces after washing and scrubbing, and pre-treatment with this product prevented S. aureus surface colonization for up to 30 days. In comparison, pre-treatment with 70% ethanol or 0.6% sodium hypochlorite was not protective against S. aureus biofilm formation after seven days. The field test demonstrated that weekly applications of the test product were more effective at reducing surface bacterial load than daily applications of a control product.
The test product conferred greater long-term protection against bacterial growth and biofilm formation by S. aureus than ethanol and sodium hypochlorite. Even with less frequent applications, the test product maintained a high level of antimicrobial activity.
本研究旨在评估一种基于有机硅的、市售的抗菌制剂在 My-shield®产品系列中的功效，以对抗细菌表面污染。
该抗菌产品在体外进行了长期持久表面抗菌活性测试，并与 70%乙醇和 0.1%或 0.6%次氯酸钠进行了比较，评估其对金黄色葡萄球菌生物膜的效果。还在一所大学的体育设施中进行了为期 6 周的现场测试。体外研究表明，测试产品、70%乙醇和 0.1%次氯酸钠的对数减少分别为 3.6、3.1 和 3.2。该测试产品在清洗和擦洗后仍能在表面上持久存在，并且该产品的预处理可防止金黄色葡萄球菌表面定植长达 30 天。相比之下，70%乙醇或 0.6%次氯酸钠预处理对金黄色葡萄球菌生物膜形成没有保护作用，7 天后生物膜形成。现场测试表明，每周应用测试产品比每日应用对照产品更有效地降低表面细菌负荷。
与乙醇和次氯酸钠相比，测试产品对金黄色葡萄球菌的生长和生物膜形成提供了更长时间的保护。即使应用频率较低，测试产品仍保持高水平的抗菌活性。
