Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China.
Department of Gynecology and Obstetrics, Zibo 148 Hospital, Zibo, 255399, Shandong Province, China.
Sci Rep. 2024 Sep 3;14(1):20478. doi: 10.1038/s41598-024-71708-5.
A single-blind, randomized controlled trial comparing oxycodone and fentanyl for patient-controlled intravenous analgesia (PCIA) after laparoscopic hysteromyomectomy found comparable pain relief between the two groups. The study included 60 participants, with NRS scores for pain at rest and when moving showing no significant differences between oxycodone and fentanyl groups at various time points postoperatively. Self-rating depression scale scores were also similar between the groups at 48 h. However, patients' satisfaction with PCIA was higher in the oxycodone group, with 73.3% reporting being very satisfied compared to 36.7% in the fentanyl group. Additionally, the oxycodone group had fewer incidences of headaches within 48 h postoperatively compared to the fentanyl group. These findings suggest that oxycodone may offer comparable pain relief, higher patient satisfaction, and fewer headaches for patients undergoing laparoscopic hysteromyomectomy compared to fentanyl, making it a suitable option for postoperative pain management in this population.Clinical trial registration number The study was registered with CHICTR.org, ChiCTR2100051924.
一项比较羟考酮和芬太尼用于腹腔镜子宫肌瘤切除术患者自控静脉镇痛（PCIA）的单盲、随机对照试验发现，两组患者的疼痛缓解情况相当。该研究纳入了 60 名参与者，术后不同时间点的静息和活动时 NRS 疼痛评分显示，羟考酮组和芬太尼组之间没有显著差异。48 小时时，两组患者的自评抑郁量表评分也相似。然而，羟考酮组患者对 PCIA 的满意度更高，73.3%的患者表示非常满意，而芬太尼组只有 36.7%。此外，与芬太尼组相比，羟考酮组术后 48 小时内头痛的发生率更低。这些发现表明，与芬太尼相比，羟考酮可为接受腹腔镜子宫肌瘤切除术的患者提供相当的疼痛缓解、更高的患者满意度和更少的头痛，使其成为该人群术后疼痛管理的一种合适选择。临床试验注册号：该研究在中国临床试验注册中心（ChiCTR2100051924）注册。
