Hind C R, Winearls C G, Pepys M B
Eur J Clin Invest. 1985 Apr;15(2):89-94. doi: 10.1111/j.1365-2362.1985.tb00150.x.
In a prospective study over 2 years, serum C-reactive protein (CRP) concentration and erythrocyte sedimentation rate were measured serially in thirty-eight patients with various types of necrotizing systemic vasculitis. The CRP concentration was always elevated in patients with active vasculitis and fell rapidly in association with clinical remission induced by immunosuppression. During periods of complete remission, in the absence of any intercurrent condition, the value remained within the normal range. In contrast the sedimentation rate responded more slowly to changes in disease activity and did not necessarily reflect the level of inflammation at a particular time. These results, together with the commercial availability of rapid and precise assays for CRP, indicate that serial measurement of the serum CRP fills the urgent need for an objective index of the activity of the systemic vasculitides and their response to therapy.
在一项为期两年的前瞻性研究中，对38例各种类型的坏死性系统性血管炎患者连续测量血清C反应蛋白（CRP）浓度和红细胞沉降率。活动性血管炎患者的CRP浓度始终升高，并且随着免疫抑制诱导的临床缓解而迅速下降。在完全缓解期，在没有任何并发疾病的情况下，该值保持在正常范围内。相比之下，沉降率对疾病活动变化的反应较慢，不一定反映特定时间的炎症水平。这些结果，再加上CRP快速精确检测方法的商业可用性，表明血清CRP的连续测量满足了对系统性血管炎活动及其对治疗反应的客观指标的迫切需求。
