Blann A D
Department of Surgery, University Hospital of South Manchester, UK.
Z Rheumatol. 1991 Sep-Oct;50(5):320-2.
Plasma von Willebrand factor antigen concentrations in 125 patients with connective tissues diseases were compared to the levels of the acute phase reactant C-reactive protein, with rheumatoid factor and with erythrocyte sedimentation rate. There was a positive correlation between von Willebrand factor antigen and C-reactive protein, but no correlation with rheumatoid factor or erythrocyte sedimentation rate. There were, however, a significant number of instances of high C-reactive protein with low von Willebrand factor antigen, and also low C-reactive protein with high von Willebrand factor antigen. Although von Willebrand factor antigen may be regarded as an acute phase reactant, high levels in the absence of other indicators of an acute phase response may be suggestive of damage/injury to the endothelium.
对125例结缔组织病患者的血浆血管性血友病因子抗原浓度与急性期反应物C反应蛋白水平、类风湿因子水平及红细胞沉降率进行了比较。血管性血友病因子抗原与C反应蛋白之间呈正相关，但与类风湿因子或红细胞沉降率无相关性。然而，存在大量C反应蛋白水平高而血管性血友病因子抗原水平低的情况，以及C反应蛋白水平低而血管性血友病因子抗原水平高的情况。虽然血管性血友病因子抗原可被视为一种急性期反应物，但在缺乏急性期反应其他指标的情况下其高水平可能提示内皮损伤。
