Cheeseman K H, Proudfoot K A, Maddix S P, Collins M M, Milia A, Slater T F
FEBS Lett. 1985 May 20;184(2):343-6. doi: 10.1016/0014-5793(85)80635-9.
Hepatic microsomal lipid peroxidation has been studied in 4 inbred strains of mice: C57BL/6, BALB/c, AKR and DBA/2. The rates of lipid peroxidation stimulated in vitro by carbon tetrachloride, ascorbate-iron and cumene hydroperoxide were similar in all 4 strains. Lipid peroxidation induced by NADPH/ADP-iron, however, proceeded at a substantially lower rate in the hepatic microsomes of DBA/2 mice. It is suggested that this low rate of enzymic iron-induced lipid peroxidation is a factor that may be involved in the resistance of this strain of mice to experimental hepatic porphyria induced by polyhalogenated aromatic hydrocarbons.
已对4种近交系小鼠（C57BL/6、BALB/c、AKR和DBA/2）的肝微粒体脂质过氧化进行了研究。四氯化碳、抗坏血酸-铁和氢过氧化异丙苯在体外刺激的脂质过氧化速率在所有4个品系中相似。然而，NADPH/ADP-铁诱导的脂质过氧化在DBA/2小鼠的肝微粒体中进行的速率要低得多。有人提出，这种酶促铁诱导的脂质过氧化低速率可能是该品系小鼠对多卤代芳烃诱导的实验性肝卟啉症具有抗性的一个因素。
