NADPH诱导的大鼠肝微粒体组分脂质过氧化反应动力学与年龄的关系。
Kinetics of NADPH-induced lipid peroxidation in rat liver microsomal fractions as a function of age.
作者信息
Devasagayam T P, Pushpendran C K
出版信息
Biochem Int. 1985 Dec;11(6):833-9.
PMID:3937529
Abstract
The kinetics of NADPH-induced lipid peroxidation in hepatic rough and smooth microsomes have been studied in rats ranging in age from 1 day to 2 years. Apparent Km and Vmax for NADPH and the extent of lipid peroxidation show that lipid peroxidation potential is low at birth, increases during postnatal development, and decreases during senescence. Our results indicate that this trend may be due to changes in phospholipid content and NADPH cytochrome c reductase activity in microsomal fractions.
摘要
对年龄从1天到2岁的大鼠肝脏粗面和滑面微粒体中NADPH诱导的脂质过氧化动力学进行了研究。NADPH的表观米氏常数（Km）和最大反应速度（Vmax）以及脂质过氧化程度表明，脂质过氧化潜能在出生时较低，在出生后发育过程中增加，而在衰老过程中降低。我们的结果表明，这种趋势可能是由于微粒体组分中磷脂含量和NADPH细胞色素c还原酶活性的变化所致。
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