Ragni G, Bestetti O, Santoro A, Viviani S, Di Pietro R, De Lauretis L
Fertil Steril. 1985 Jun;43(6):927-30. doi: 10.1016/s0015-0282(16)48624-3.
The reproductive capacities of 35 patients with Hodgkin's disease were assessed before treatment by semen evaluation and determination of basal hypothalamic-hypophyseal function and after stimulation with gonadotropin-releasing hormone (GnRH). Sixty-five percent of the patients had asthenozoospermia, 46% had teratozoospermia, and 28% had oligozoospermia. Normal semen was more frequently seen in asymptomatic patients (7 of 18) than in symptomatic patients (2 of 15). All the patients had normal basal follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels and significantly low testosterone (T) levels (P less than 0.01). The FSH response to 100 micrograms of GnRH was normal, but the LH responses were all significantly low, both as delta % (28.4% +/- 18.7% versus 52.4% +/- 25.3%, P less than 0.005) and as peak values (36.7 +/- 20.7 mIU/ml versus 59.4 +/- 26.4 mIU/ml, P less than 0.01). It is believed that abnormal semen is a specific symptom of Hodgkin's disease, secondary to functional insufficiency of the hypothalamic-hypophyseal axis, with a relative decrease in T production.
在治疗前，通过精液评估以及基础下丘脑 - 垂体功能测定，并在促性腺激素释放激素（GnRH）刺激后，对35例霍奇金病患者的生殖能力进行了评估。65%的患者存在弱精子症，46%的患者存在畸形精子症，28%的患者存在少精子症。无症状患者（18例中的7例）比有症状患者（15例中的2例）更常出现正常精液。所有患者的基础促卵泡生成素（FSH）和促黄体生成素（LH）水平正常，但睾酮（T）水平显著降低（P < 0.01）。对100微克GnRH的FSH反应正常，但LH反应均显著降低，无论是以Δ%（28.4%±18.7%对52.4%±25.3%，P < 0.005）还是以峰值（36.7±20.7 mIU/ml对59.4±26.4 mIU/ml，P < 0.01）来衡量。据信，异常精液是霍奇金病的一种特定症状，继发于下丘脑 - 垂体轴功能不全，伴有T生成相对减少。
