Magnanti M, Malizia S, Garufi G, Lenzi A, Anselmo A P, Beligotti F, Fabbrini A, Santiemma V
Dipartimento di Fisiopatologia Medica, Università di Roma La Sapienza, Rome, Italy.
J Cancer Res Clin Oncol. 1996;122(7):416-20. doi: 10.1007/BF01212881.
The aim of this work was to characterize further the impairment of the reproductive function reported in untreated male patients with Hodgkin's disease. We evaluated the pattern of luteinizing hormone pulsatility and unconventional sperm features by computer-assisted sperm analysis (CASA) in 20 adult patients affected by biopsy-proven Hodgkin's disease before they were submitted to any therapeutic approach. Changes of luteinizing hormone pulsatility were documented and consisted mainly in an increase in pulse number in comparison with control subjects (P < 0.05). On CASA, 1/3 of the patients showed a reduction in the sperm number but, when motility, velocity and linearity of progression were evaluated, the number of patients with seminal alterations rose to 2/3. Sperm velocity and linearity were already impaired in stages I and II, whereas sperm number was reduced only in stage III. Symptomatic patients, regardless of the stage, showed a significant deterioration of all parameters. Our study supports the view that in Hodgkin's disease, before any treatment, a disorder of the reproductive system is present, both at hypothalamic/hypophysial and the gonadal level, having a pathogenesis that deserves to be elucidated by further study.
这项工作的目的是进一步描述未经治疗的男性霍奇金病患者所报告的生殖功能损害情况。我们通过计算机辅助精子分析（CASA）评估了20例经活检证实患有霍奇金病的成年患者在接受任何治疗方法之前的促黄体生成素脉冲模式和非常规精子特征。记录了促黄体生成素脉冲的变化，主要表现为与对照组相比脉冲次数增加（P < 0.05）。在CASA检测中，1/3的患者精子数量减少，但在评估精子活力、速度和前进线性时，精液改变的患者数量增至2/3。在I期和II期精子速度和线性就已受损，而精子数量仅在III期减少。有症状的患者，无论处于何阶段，所有参数均显著恶化。我们的研究支持这样一种观点，即在霍奇金病中，在任何治疗之前，下丘脑/垂体和性腺水平均存在生殖系统紊乱，其发病机制值得进一步研究阐明。
