Laboratory BVBGR-LR11ES31, Institute of Biotechnology of Sidi Thabet, University of Manouba, Tunisia.
Doctoral School in Sciences and Technologies of Computing, Communications, Design and the Environment, University of Manouba, Tunisia.
Phytother Res. 2024 Nov;38(11):5309-5322. doi: 10.1002/ptr.8319. Epub 2024 Sep 3.
Resveratrol (RSV), a bioactive natural phenolic compound found in plants, fruits, and vegetables, has garnered significant attention in pharmaceutical, food, and cosmetic industries due to its remarkable biological and pharmacological activities. Despite its potential in treating various diseases, its poor pharmacokinetic properties, such as low solubility, stability, bioavailability, and susceptibility to rapid oxidation, limit its biomedical applications. Recent advancements focus on incorporating resveratrol into innovative materials like nanoparticles, polymers, and bio-ceramics to enhance its properties and bioavailability. In this review, an exhaustive literature search was conducted from PubMed, Google Scholar, Science Direct, Scopus, and Web of Science databases to explore these advancements, to compares conventional and innovative extraction methods, and to highlights resveratrol's therapeutic potential, including its anti-inflammatory, anti-oxidative, anti-cancerogenic, antidiabetic, neuroprotective, and cardio-protective properties. Additionally, we discuss the challenges and prospects of hybrid materials combining resveratrol with nanoparticles, polymers, and bio-ceramics for therapeutic applications. Rigorous studies are still needed to confirm their clinical efficacy.
白藜芦醇（RSV）是一种存在于植物、水果和蔬菜中的生物活性天然酚类化合物，由于其显著的生物学和药理学活性，在制药、食品和化妆品行业引起了广泛关注。尽管它在治疗各种疾病方面具有潜力，但由于其较差的药代动力学特性，如低溶解度、稳定性、生物利用度和易被快速氧化，限制了其在生物医学中的应用。最近的研究重点是将白藜芦醇纳入纳米粒子、聚合物和生物陶瓷等创新材料中，以提高其性能和生物利用度。在这篇综述中，我们从 PubMed、Google Scholar、Science Direct、Scopus 和 Web of Science 数据库进行了全面的文献检索，以探讨这些进展，比较传统和创新的提取方法，并强调白藜芦醇的治疗潜力，包括其抗炎、抗氧化、抗癌、抗糖尿病、神经保护和心脏保护特性。此外，我们还讨论了将白藜芦醇与纳米粒子、聚合物和生物陶瓷结合的混合材料在治疗应用中的挑战和前景。仍需要进行严格的研究来确认它们的临床疗效。
