Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai-400056, India.
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai-400056, India.
Phytomedicine. 2020 Jun;71:153240. doi: 10.1016/j.phymed.2020.153240. Epub 2020 May 15.
Bioflavonoids, secondary metabolites of plants, are beneficial in regulating human physiological mechanisms. Bioflavonoids majorly exist in the dietary intake of fruits, vegetables, legumes, pulses, etc. In addition to their cardio-protective and neuroprotective activities, they also possess prominent pharmacological effects including anti-oxidant, anti-inflammatory, anti-proliferative and anti-thrombogenic actions. However, therapeutic efficacy of the bioflavonoids is hampered by their lipophilic nature, low solubility and variable bioavailability which catch the eyes of formulation scientists.
Nanocrystal formulations were studied for many bioflavonoids, although enough attention has not been given to their commercial exploitation, unlike drug nanocrystals. Nanocrystals of bioflavonoid can be prepared by top-down technique, bottom-up technique or combination of both. This review primarily focuses on nanocrystal technology for bioflavonoids, methods of production, critical process parameters, in vitro and in vivo studies conducted to evaluate the efficiency.
The detailed literature survey was systematically carried out using different electronic databases. It includes Scopus, Web of Science, Medline via PubMed, EMBASE, and Google Scholar. Also up-to-date patent search was conducted to understand the prior art and available intellectual properties.
It was observed that several formulation and process parameters have an impact on flavonoids nanocrystals and their therapeutic efficacy. Also, clinical studies of flavonoid nanocrystals are barely done so far and thus, substantial safety and efficacy data is necessary for its commercial applications. Nevertheless, nanocrystals can be explored as a promising technology platform for improving overall therapeutic performance of flavonoids in future.
生物类黄酮是植物的次生代谢产物，有益于调节人体生理机制。生物类黄酮主要存在于水果、蔬菜、豆类、豆科植物等的饮食摄入中。除了具有心脏保护和神经保护活性外，它们还具有突出的药理作用，包括抗氧化、抗炎、抗增殖和抗血栓形成作用。然而，生物类黄酮的治疗功效受到其亲脂性、低溶解度和可变生物利用度的限制，这引起了制剂科学家的关注。
已经对许多生物类黄酮进行了纳米晶体制剂研究，尽管与药物纳米晶体相比，它们的商业开发还没有得到足够的重视。生物类黄酮纳米晶体可以通过自上而下的技术、自下而上的技术或两者的组合来制备。本综述主要关注生物类黄酮的纳米晶体技术、生产方法、关键工艺参数，以及进行的体外和体内研究以评估其效率。
使用不同的电子数据库系统地进行了详细的文献调查。这些数据库包括 Scopus、Web of Science、Medline via PubMed、EMBASE 和 Google Scholar。还进行了最新的专利搜索，以了解现有技术和可用的知识产权。
研究发现，有几个制剂和工艺参数对类黄酮纳米晶体及其治疗效果有影响。此外，目前为止几乎没有对类黄酮纳米晶体进行临床研究，因此需要进行大量的安全性和疗效数据研究，以促进其商业应用。尽管如此，纳米晶体仍可以作为一种有前途的技术平台，用于提高类黄酮的整体治疗性能。
