Mori S, Takanashi M, Motoji T, Shiozaki H, Oshimi K, Mizoguchi H
Jpn J Cancer Res. 1985 Mar;76(3):208-12.
Neoplastic angioendotheliosis (NAE) is a rare disease characterized by the occlusion of small vessels by apparently neoplastic medium-sized cells. The origin of these cells remains undetermined, mainly because the diagnosis in most of these cases has been made on autopsy. This report describes a case of NAE from whom a biopsy specimen was obtained and studied immunohistologically. The cells occluding small vessels of this patient bear B cell markers such as monoclonal immunoglobulin (mu, lambda), Leu14, B1, OKB2, and Dako-PanB, whereas they do not react with antibodies against delta- and kappa-chain of immunoglobulin (Ig), or antibodies against markers of T cells, myelomonocytic cells and endothelial cells. These results show clearly that the cells occluding the small vessels of this patient are neoplastic and of B cell lineage. This is the first case of NAE in whom the neoplastic cells in the blood vessels have been proved to be of lymphocytic lineage.
肿瘤性血管内皮增生症（NAE）是一种罕见疾病，其特征为小血管被明显呈肿瘤性的中等大小细胞阻塞。这些细胞的起源尚未确定，主要是因为大多数此类病例的诊断是在尸检时做出的。本报告描述了一例获取活检标本并进行免疫组织学研究的NAE病例。该患者阻塞小血管的细胞带有B细胞标志物，如单克隆免疫球蛋白（μ、λ）、Leu14、B1、OKB2和Dako - PanB，而它们不与抗免疫球蛋白（Ig）δ链和κ链的抗体反应，也不与抗T细胞、骨髓单核细胞和内皮细胞标志物的抗体反应。这些结果清楚地表明，该患者阻塞小血管的细胞是肿瘤性的且为B细胞谱系。这是第一例血管中的肿瘤细胞被证实为淋巴细胞谱系的NAE病例。
