Theaker J M, Gatter K C, Esiri M M, Easterbrook P
Histopathology. 1986 Dec;10(12):1261-70. doi: 10.1111/j.1365-2559.1986.tb02569.x.
Neoplastic angioendotheliosis is a rare condition, most commonly presenting with a bizarre neurological illness associated with multifocal cerebral infarction due to the occlusion of small blood vessels by neoplastic cells. The histogenesis of the malignant cells is controversial with previous suggestions of an endothelial, epithelial or lymphoid origin. We have studied a case immunohistologically using a panel of monoclonal and polyclonal antibodies recognizing a range of lymphoid, endothelial and epithelial antigens. The results indicate that the malignant cells were of B-lymphoid origin. We also report a second case in which a patient with a high grade B-cell non-Hodgkin's lymphoma developed multiple painful skin nodules which showed the histological features of neoplastic angioendotheliosis. These findings support the view that neoplastic angioendotheliosis is a lymphoma with a propensity to localize and proliferate in small blood vessels throughout the body.
肿瘤性血管内皮细胞增生症是一种罕见病症，最常见的表现是一种怪异的神经系统疾病，伴有因肿瘤细胞阻塞小血管导致的多灶性脑梗死。恶性细胞的组织发生存在争议，此前有观点认为其起源于内皮、上皮或淋巴组织。我们使用一组识别多种淋巴、内皮和上皮抗原的单克隆和多克隆抗体，对一例病例进行了免疫组织学研究。结果表明，恶性细胞起源于B淋巴细胞。我们还报告了第二例病例，一名高级别B细胞非霍奇金淋巴瘤患者出现了多个疼痛性皮肤结节，这些结节具有肿瘤性血管内皮细胞增生症的组织学特征。这些发现支持了这样一种观点，即肿瘤性血管内皮细胞增生症是一种倾向于在全身小血管中定位和增殖的淋巴瘤。
