重症肌无力与2019冠状病毒病：一项系统评价与荟萃分析
Myasthenia Gravis and COVID-19: A Systematic Review and Meta-analysis.
作者信息
Nafari Amirhossein, Shojaei Seyedpouzhia, Khoshnood Reza Jalili, Ghajarzadeh Mahsa, Tafreshinejad Arash, Safari Saeid, Mirmosayyeb Omid
机构信息
Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Critical Care Quality Improvement Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Basic Clin Neurosci. 2024 Mar-Apr;15(2):175-184. doi: 10.32598/bcn.2023.4360.5. Epub 2024 Mar 1.
INTRODUCTION
Patients with myasthenia gravis (MG), an autoimmune disease affecting the neuromuscular junction, exhibits varying rates of COVID-19 infection across different studies. This systematic review and meta-analysis aim to estimate the pooled prevalence of COVID-19 infection in individuals with MG.
METHODS
We systematically searched PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and gray literature, including references to the research published before October 2021. The total number of participants, the first author, the publication year, the country of origin, the number of MG patients, their symptoms, hospitalization rates, and deaths were all extracted as study data.
RESULTS
Our literature search yielded 253 articles, of which 75 remained after removing duplicates. Finally, 18 articles were included in the meta-analysis. The pooled prevalence of COVID-19 infection in MG cases was found to be 2% (95% CI, 1%, 3%; I=85%, P<0.001). Additionally, the pooled prevalence of hospitalization among those with COVID-19 infection was 43% (95% CI, 26%, 60%; I=97.6%; P<0.001), and the pooled prevalence of MG exacerbation was 33% (95% CI, 20%, 46%; I=92.6%; P<0.001).
CONCLUSION
In summary, this systematic review and meta-analysis reveal that the pooled prevalence of COVID-19 infection in individuals with MG is 2%.
引言
重症肌无力（MG）是一种影响神经肌肉接头的自身免疫性疾病，不同研究中MG患者的新冠病毒感染率各不相同。本系统评价和荟萃分析旨在估计MG患者中新冠病毒感染的合并患病率。
方法
我们系统检索了PubMed、Scopus、EMBASE、Web of Science、谷歌学术以及灰色文献，包括2021年10月之前发表的研究参考文献。提取的研究数据包括参与者总数、第一作者、发表年份、原产国、MG患者数量、症状、住院率和死亡人数。
结果
我们的文献检索共得到253篇文章，去除重复后还剩75篇。最终，18篇文章纳入荟萃分析。MG患者中新冠病毒感染的合并患病率为2%（95%可信区间，1%，3%；I² = 85%，P < 0.001）。此外，新冠病毒感染患者的合并住院患病率为43%（95%可信区间，26%，60%；I² = 97.6%；P < 0.001），MG病情加重的合并患病率为33%（95%可信区间，20%，46%；I² = 92.6%；P < 0.001）。
结论
总之，本系统评价和荟萃分析表明，MG患者中新冠病毒感染的合并患病率为2%。
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