Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Comprehensive Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Neurol Sci. 2022 Feb;43(2):775-783. doi: 10.1007/s10072-021-05756-4. Epub 2021 Nov 17.
Patients with Parkinson's disease (PD) are at higher risk of COVID-19 infection as most of them are at older age. The goal of this study is to update the pooled prevalence of COVID-19 infection in patients with PD.
Two researchers systematically searched PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and also gray literature including references of the included studies which were published before September 2021. We extracted data regarding the total number of participants, first author, publication year, the country of origin, mean age, number with COVID-19, symptoms, hospitalization, and death.
We found 1693 articles by literature search; after deleting duplicates, 798 remained. Thirty articles remained for meta-analysis. The pooled prevalence of COVID-19 infection in PD cases was 5% (95%CI: 4-6%) (I = 98.1%, P < 0.001). The pooled prevalence of fever in cases with PD was 4% (95%CI: 2-6%) (I = 96%, P < 0.001). The pooled prevalence of cough in cases with PD was 3% (95%CI: 2-4%) (I = 95.9%, P < 0.001). The pooled prevalence of hospitalization in cases with COVID-19 infection was 49% (95%CI: 29-52%) (I: 93.5%, P < 0.001). The pooled prevalence of mortality in COVID-19 cases was 12% (95%CI: 10-14%) (I = 97.6%, P < 0.001).
The results of this systematic review and meta-analysis show that the pooled prevalence of COVID-19 infection in PD cases is 5% besides hospitalization and mortality rates which are 49% and 12%.
由于大多数帕金森病 (PD) 患者年龄较大，因此他们感染 COVID-19 的风险更高。本研究的目的是更新 PD 患者 COVID-19 感染的汇总患病率。
两名研究人员系统地检索了 PubMed、Scopus、EMBASE、Web of Science、Google Scholar 以及包括 2021 年 9 月前已发表研究参考文献的灰色文献。我们提取了有关参与者总数、第一作者、发表年份、原籍国、平均年龄、COVID-19 患者人数、症状、住院和死亡的数据。
通过文献检索发现 1693 篇文章；删除重复项后，剩余 798 篇。有 30 篇文章用于荟萃分析。PD 病例 COVID-19 感染的汇总患病率为 5%（95%CI：4-6%）（I=98.1%，P<0.001）。PD 病例发热的汇总患病率为 4%（95%CI：2-6%）（I=96%，P<0.001）。PD 病例咳嗽的汇总患病率为 3%（95%CI：2-4%）（I=95.9%，P<0.001）。COVID-19 感染病例住院的汇总患病率为 49%（95%CI：29-52%）（I：93.5%，P<0.001）。COVID-19 病例死亡的汇总患病率为 12%（95%CI：10-14%）（I=97.6%，P<0.001）。
本系统评价和荟萃分析的结果表明，PD 患者 COVID-19 感染的汇总患病率为 5%，住院率和死亡率分别为 49%和 12%。
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