Rayamajhi Aadesh, Rayamajhi Sandesh, Agrawal Saurav, Gautam Niraj
Maharajgunj Medical Campus, Tribhuvan University, Institute of Medicine, Maharajgunj, Kathmandu 44606, Nepal.
Nepalese Army Institute of Health Sciences College of Medicine, Bhandarkhal, Sanobharyang, Kathmandu 44601, Nepal.
Oxf Med Case Reports. 2024 Sep 2;2024(9):omae099. doi: 10.1093/omcr/omae099. eCollection 2024 Sep.
Dengue, caused by the dengue virus, presents with various clinical manifestations, including rare neurological complications. Guillain-Barre Syndrome (GBS), an immune-mediated polyradiculoneuropathy, is a rare complication, often triggered by antecedent infections. Herein, we report the case of a 30-year-old male presenting with GBS following dengue fever. His clinical course revealed classic GBS symptoms, including ascending weakness and bulbar involvement, with no noted infection that could plausibly explain a trigger for GBS. Diagnosis entailed cerebrospinal fluid analysis and nerve conduction studies which confirmed acute inflammatory demyelinating polyradiculoneuropathy. Treatment involved plasmapheresis, yielding a positive response. This case underscores the association between dengue and GBS, emphasizing the need for heightened clinical suspicion in endemic regions like Nepal.
登革热由登革病毒引起，有多种临床表现，包括罕见的神经并发症。吉兰 - 巴雷综合征（GBS）是一种免疫介导的多发性神经根神经病，是一种罕见的并发症，常由先前感染引发。在此，我们报告一例30岁男性在登革热后出现吉兰 - 巴雷综合征的病例。他的临床病程显示出典型的吉兰 - 巴雷综合征症状，包括进行性肌无力和延髓受累，未发现可合理解释吉兰 - 巴雷综合征触发因素的感染。诊断需要进行脑脊液分析和神经传导研究，结果证实为急性炎症性脱髓鞘性多发性神经根神经病。治疗采用血浆置换，取得了积极效果。该病例强调了登革热与吉兰 - 巴雷综合征之间的关联，凸显了在尼泊尔等流行地区提高临床怀疑意识的必要性。
