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南亚区域合作联盟（SAARC）地区登革热的流行病学：系统评价和荟萃分析。

Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis.

机构信息

Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL, USA.

Department of Internal Medicine, Bronxcare Health System, Bronx, NY, USA.

出版信息

Parasit Vectors. 2022 Oct 24;15(1):389. doi: 10.1186/s13071-022-05409-1.

DOI:10.1186/s13071-022-05409-1
PMID:36280877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9594905/
Abstract

BACKGROUND

Dengue is one of the common arboviral infections and is a public health problem in South East Asia. The aim of this systematic review and meta-analysis was to evaluate the prevalence and distribution of dengue in SAARC (South Asian Association for Regional Cooperation) countries.

METHODS

The PubMed, PubMed Central, Embase and Scopus databases were searched for relevant studies. Statistical analysis on data extracted from the selected studied was conducted using the Comprehensive Meta-Analysis Software (CMA) version 3 software package. Proportions were used to estimate the outcome with a 95% confidence interval (CI).

RESULTS

Across all studies, among cases of suspected dengue, 30.7% were confirmed dengue cases (proportion: 0.307, 95% CI: 0.277-0.339). The seroprevalence of dengue immunoglobulin (Ig)G, IgM or both (IgM and IgG) antibodies and dengue NS1 antigen was 34.6, 34.2, 29.0 and 24.1%, respectively. Among the different strains of dengue, dengue virus (DENV) strains DENV-1, DENV-2, DENV-3 and DENV-4 accounted for 21.8, 41.2, 14.7 and 6.3% of cases, respectively. The prevalence of dengue fever, dengue hemorrhagic fever and dengue shock syndrome was 80.5, 18.2 and 1.5%, respectively. Fever was a commonly reported symptom, and thrombocytopenia was present in 44.7% of cases. Mortality was reported in 1.9% of dengue cases.

CONCLUSIONS

Dengue is a common health problem in South East Asia with high seroprevalence. DENV-2 was found to be the most common strain causing infection, and most dengue cases were dengue fever. In addition, thrombocytopenia was reported in almost half of the dengue cases.

摘要

背景

登革热是常见的虫媒病毒感染之一，也是东南亚的一个公共卫生问题。本系统评价和荟萃分析的目的是评估南亚区域合作联盟（SAARC）国家登革热的流行率和分布。

方法

检索了 PubMed、PubMed Central、Embase 和 Scopus 数据库中相关的研究。使用 Comprehensive Meta-Analysis Software (CMA) version 3 软件包对从选定研究中提取的数据进行统计分析。使用 95%置信区间（CI）的比例来估计结果。

结果

在所有研究中，在疑似登革热病例中，30.7%为确诊登革热病例（比例：0.307，95%CI：0.277-0.339）。登革热免疫球蛋白（Ig）G、IgM 或两者（IgM 和 IgG）抗体和登革热 NS1 抗原的血清流行率分别为 34.6%、34.2%、29.0%和 24.1%。在不同的登革热株中，登革病毒（DENV）株 DENV-1、DENV-2、DENV-3 和 DENV-4 分别占病例的 21.8%、41.2%、14.7%和 6.3%。登革热、登革出血热和登革休克综合征的流行率分别为 80.5%、18.2%和 1.5%。发热是常见的症状，血小板减少症见于 44.7%的病例。登革热病例的死亡率为 1.9%。

结论

登革热是东南亚常见的卫生问题，血清流行率较高。DENV-2 是最常见的引起感染的株，大多数登革热病例为登革热。此外，近一半的登革热病例报告有血小板减少症。

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