Hirakawa Hirofumi, Terao Takeshi
Department of Neuropsychiatry, Oita University Faculty of Medicine, Yufu, Oita, Japan.
Front Psychiatry. 2024 Aug 20;15:1414776. doi: 10.3389/fpsyt.2024.1414776. eCollection 2024.
Bipolar disorder is a chronic disorder characterized by fluctuations in mood state and energy and recurrent episodes of mania/hypomania and depression. Bipolar disorder may be regarded as a neuro-progressive disorder in which repeated mood episodes may lead to cognitive decline and dementia development. In the current review, we employed genome-wide association studies to comprehensively investigate the genetic variants associated with bipolar disorder and dementia. Thirty-nine published manuscripts were identified: 20 on bipolar disorder and 19 on dementia. The results showed that the genes CACNA1C, GABBR2, SCN2A, CTSH, MSRA, and SH3PXD2A were overlapping between patients with bipolar disorder and dementia. In conclusion, the genes CACNA1C, GABBR2, SCN2A, CTSH, MSRA, and SH3PXD2A may be associated with the neuro-progression of bipolar disorder to dementia. Further genetic studies are needed to comprehensively clarify the role of genes in cognitive decline and the development of dementia in patients with bipolar disorder.
双相情感障碍是一种慢性疾病，其特征为情绪状态和精力的波动以及躁狂/轻躁狂和抑郁的反复发作。双相情感障碍可被视为一种神经退行性疾病，其中反复的情绪发作可能导致认知能力下降和痴呆症的发展。在当前的综述中，我们采用全基因组关联研究来全面调查与双相情感障碍和痴呆症相关的基因变异。我们识别出了39篇已发表的手稿：20篇关于双相情感障碍，19篇关于痴呆症。结果表明，基因CACNA1C、GABBR2、SCN2A、CTSH、MSRA和SH3PXD2A在双相情感障碍患者和痴呆症患者中存在重叠。总之，基因CACNA1C、GABBR2、SCN2A、CTSH、MSRA和SH3PXD2A可能与双相情感障碍向痴呆症的神经进展有关。需要进一步的基因研究来全面阐明基因在双相情感障碍患者认知能力下降和痴呆症发展中的作用。
