Liu Zimo, Xie Wenqing, Li Hengzhen, Liu Xu, Lu Yao, Lu Bangbao, Deng Zhenhan, Li Yusheng
Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Xiangya School of Medicine, Central South University, Changsha, Hunan 410083, China.
Genes Dis. 2023 Nov 4;11(6):101159. doi: 10.1016/j.gendis.2023.101159. eCollection 2024 Nov.
Osteoarthritis (OA) is a common chronic joint disease characterized by articular cartilage degeneration, subchondral sclerosis, synovitis, and osteophyte formation. OA is associated with disability and impaired quality of life, particularly among the elderly. Leptin, a 16-kD non-glycosylated protein encoded by the obese gene, is produced on a systemic and local basis in adipose tissue and the infrapatellar fat pad located in the knee. The metabolic mechanisms employed by leptin in OA development have been widely studied, with attention being paid to aging as a corroborative risk factor for OA. Hence, in this review, we have attempted to establish a potential link between leptin and OA, by focusing on aging-associated mechanisms and proposing leptin as a potential diagnostic and therapeutic target in aging-related mechanisms of OA that may provide fruitful guidance and emphasis for future research.
骨关节炎（OA）是一种常见的慢性关节疾病，其特征为关节软骨退变、软骨下硬化、滑膜炎和骨赘形成。OA与残疾和生活质量受损相关，在老年人中尤为明显。瘦素是一种由肥胖基因编码的16-kD非糖基化蛋白，在脂肪组织和位于膝关节的髌下脂肪垫中全身性和局部性地产生。瘦素在OA发展中所采用的代谢机制已得到广泛研究，衰老作为OA的一个佐证性风险因素也受到关注。因此，在本综述中，我们试图通过关注与衰老相关的机制，并提出瘦素作为OA衰老相关机制中的潜在诊断和治疗靶点，来建立瘦素与OA之间的潜在联系，这可能为未来的研究提供富有成效的指导和重点。
