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一种被忽视的疾病:化脓性汗腺炎——淀粉样变性合并脓毒症及肾衰竭的罕见病因:一例报告

A Neglected Disease: Hidradenitis Suppurativa a Rare Cause of Amyloidosis Complicated With Sepsis and Renal Failure: A Case Report.

作者信息

Demir Orhun, Yondem Omer Zuhtu, Doganay Mehmet

机构信息

Department of Anesthesiology Faculty of Medicine Lokman Hekim University, Ankara, Türkiye.

Department of Infectious Diseases Faculty of Medicine Lokman Hekim University, Ankara, Türkiye.

出版信息

Case Rep Crit Care. 2024 Aug 27;2024:4893040. doi: 10.1155/2024/4893040. eCollection 2024.

DOI:10.1155/2024/4893040
PMID:39229360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11371454/
Abstract

Hidradenitis suppurativa (HS) is a painful relapsing inflammatory disease characterized with subcutaneous nodules, abscesses, tunnels, and deforming scars. We present a case of HS complicated with amyloidosis who was admitted with sepsis and acute renal failure. A 53-year-old male patient with a history of HS and amyloidosis was accepted to the intensive care unit suffering from acute kidney failure and sepsis symptoms. He was receiving adalimumab during admission. He received hemodialysis and piperacillin-tazobactam antibiotherapy. After 15 days of hospitalization, his sepsis was treated, but he was taken to a routine hemodialysis programme. In the presence of amyloidosis with intervenient infections, the risk of chronic renal failure in HS cases can be kept in mind even if the patient is receiving TNF inhibitors.

摘要

化脓性汗腺炎(HS)是一种疼痛性复发性炎症性疾病,其特征为皮下结节、脓肿、窦道和变形瘢痕。我们报告一例HS合并淀粉样变性的病例,该患者因脓毒症和急性肾衰竭入院。一名有HS和淀粉样变性病史的53岁男性患者因急性肾衰竭和脓毒症症状入住重症监护病房。入院期间他正在接受阿达木单抗治疗。他接受了血液透析和哌拉西林-他唑巴坦抗菌治疗。住院15天后,他的脓毒症得到治疗,但随后被纳入常规血液透析方案。在存在淀粉样变性并伴有间歇性感染的情况下,即使患者正在接受肿瘤坏死因子抑制剂治疗,HS病例发生慢性肾衰竭的风险也应予以考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3669/11371454/0152acdbc2a9/CRICC2024-4893040.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3669/11371454/0152acdbc2a9/CRICC2024-4893040.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3669/11371454/0152acdbc2a9/CRICC2024-4893040.001.jpg

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本文引用的文献

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Risk of Chronic Kidney Disease in Hospitalized Patients with Hidradenitis Suppurativa.住院化脓性汗腺炎患者的慢性肾脏病风险。
Dermatology. 2023;239(6):912-918. doi: 10.1159/000531960. Epub 2023 Jul 24.
2
Hidradenitis Suppurativa: a lesser-known cause of AA amyloidosis.化脓性汗腺炎:AA型淀粉样变性的一个鲜为人知的病因。
Hippokratia. 2020 Jan-Mar;24(1):33-37.
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Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life.化脓性汗腺炎:流行病学、表型、诊断、发病机制、合并症及生活质量的最新进展
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Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa.基于人群的临床实践研究数据库研究使用算法模型来确定化脓性汗腺炎的真实负担。
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Increased Suicide Risk in Patients with Hidradenitis Suppurativa.患有化脓性汗腺炎的患者自杀风险增加。
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Cigarette smoking and chronic kidney disease in the general population: a systematic review and meta-analysis of prospective cohort studies.在普通人群中,吸烟与慢性肾脏病的关系:一项前瞻性队列研究的系统评价和荟萃分析。
Nephrol Dial Transplant. 2017 Mar 1;32(3):475-487. doi: 10.1093/ndt/gfw452.
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