壳聚糖在一种防蛋白正畸粘结剂的抗菌能力和生物相容性中的应用
The Incorporation of Chitosan in the Antibacterial Capability and Biocompatibility of a Protein-Repellent Orthodontic Cement.
作者信息
Yi Jianru, He Fan, Zhao Zhihe
机构信息
Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, CHN.
出版信息
Cureus. 2024 Aug 3;16(8):e66099. doi: 10.7759/cureus.66099. eCollection 2024 Aug.
BACKGROUND
This study aimed to develop an orthodontic cement containing chitosan and 2-methacryloyloxyethyl phosphorylcholine (MPC) and to investigate its antibacterial properties and biocompatibility.
METHODS
Chitosan and MPC were incorporated into commercial cement. The enamel bonding strength and biocompatibility of the new cement were evaluated. The antibacterial properties were assessed by examining biofilm metabolic activity and colony-forming units (CFU). An evaluation of the protein repellency of the cement was also conducted.
RESULTS
The new cement containing chitosan and MPC had clinically acceptable bonding strength. In comparison to the control, the novel cement demonstrated enhanced protein-repellent properties (p < 0.05), inhibited biofilm metabolic activity (p < 0.05), and reduced CFU counts (p < 0.05) without diminishing cell viability in response to cement extracts (p > 0.05).
CONCLUSIONS
The synergistic application of chitosan and MPC endows the cement with potent antibacterial abilities, protein repellency, and favorable biocompatibility.
背景
本研究旨在开发一种含壳聚糖和2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）的正畸粘结剂，并研究其抗菌性能和生物相容性。
方法
将壳聚糖和MPC加入商用粘结剂中。评估新型粘结剂的釉质粘结强度和生物相容性。通过检测生物膜代谢活性和菌落形成单位（CFU）来评估抗菌性能。还对粘结剂的蛋白质排斥性进行了评估。
结果
含壳聚糖和MPC的新型粘结剂具有临床上可接受的粘结强度。与对照组相比，新型粘结剂表现出增强的蛋白质排斥性能（p < 0.05），抑制生物膜代谢活性（p < 0.05），并减少CFU计数（p < 0.05），同时对粘结剂提取物的细胞活力没有影响（p > 0.05）。
结论
壳聚糖和MPC的协同应用赋予粘结剂强大的抗菌能力、蛋白质排斥性和良好的生物相容性。
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