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危重症患者术后谵妄发生的促发和诱发因素:大学重症监护病房的一项研究。

Predisposing and precipitating factors for the development of postoperative delirium in critically ill patients in a university intensive care unit.

机构信息

Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Universidade do Estado do Rio de Janeiro, Hospital Universitário Pedro Ernesto, Rio de Janeiro, RJ, Brazil.

出版信息

Rev Lat Am Enfermagem. 2024 Sep 2;32:e4233. doi: 10.1590/1518-8345.7113.4233. eCollection 2024.

DOI:10.1590/1518-8345.7113.4233
PMID:39230174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11386484/
Abstract

OBJECTIVE

to detect the incidence of postoperative delirium in critically ill patients admitted to a surgical intensive care unit and to evaluate the predisposing and precipitating factors associated with postoperative delirium in critically ill patients admitted to a surgical intensive care unit.

METHOD

this is a prospective cohort study of 157 critically ill surgical patients. Fisher's exact test and Chi-square test were used for the association between factors and the occurrence of delirium, the Wilcoxon test for numerical variables, and the logistic regression model for the analysis of predisposing and precipitating factors.

RESULTS

the incidence of delirium was 28% (n=44). Age was a significant predisposing factor (p=0.001), followed by the length of surgery (p<0.001), blood transfusion (p=0.043), administration of crystalloids (p=0.008), and anti-inflammatory drugs (p=0.037), which were the precipitating factors identified. The best-adjusted models were: age, length of surgery, non-administration of anti-emetics, use of sufentanil, and blood transfusion.

CONCLUSION

delirium is a frequent condition in critically ill adults undergoing surgery and the existence of precipitating and predisposing factors is relevant to the outcome, with the anesthetic-surgical procedure as the catalyst event.

摘要

目的

检测外科重症监护病房(SICU)中危重症患者术后谵妄的发生率,并评估与 SICU 中危重症患者术后谵妄相关的易患因素和促发因素。

方法

这是一项对 157 例外科危重症患者的前瞻性队列研究。采用 Fisher 确切检验和卡方检验评估因素与谵妄发生之间的相关性,采用 Wilcoxon 检验评估数值变量,采用 logistic 回归模型分析易患因素和促发因素。

结果

谵妄发生率为 28%(n=44)。年龄是显著的易患因素(p=0.001),其次是手术时间(p<0.001)、输血(p=0.043)、晶体液输注(p=0.008)和抗炎药物(p=0.037),这些是确定的促发因素。最佳调整模型为:年龄、手术时间、未使用止吐药、使用舒芬太尼和输血。

结论

术后谵妄是外科手术中危重症成年患者的常见并发症,易患因素和促发因素的存在与预后相关,麻醉-手术过程是诱发事件。

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Effect of sedative premedication with oral midazolam on postanesthesia care unit delirium in older adults: a secondary analysis following an uncontrolled before-after design.口服咪达唑仑镇静预处理对老年患者麻醉后监护室谵妄的影响:一项采用非对照前后设计的二次分析
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Delirium in trauma patients: a 1-year prospective cohort study of 2026 patients.创伤患者的谵妄:2026 例患者的 1 年前瞻性队列研究。
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