Ahmed Imaal, Yu Michelle, Chaves Vitoria, Xu Ruiyang, Lavallée Andréane, Warmingham Jennifer M, Firestein Morgan, Kyle Margaret H, Fisher Kaylee, Merriman Emma T, Rodriguez Cynthia, Mace Westin, Fernandez Cristina, Dumitriu Dani, Lalwani Anil K
Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Department of Otolaryngology-Head & Neck Surgery, Columbia University Irving Medical Center, New York, NY, USA.
Laryngoscope. 2025 Jan;135(1):385-392. doi: 10.1002/lary.31739. Epub 2024 Sep 4.
Given the prevalence of neonatal hearing loss (HL) associated with intrauterine viral exposures, the goal of this study is to provide information on neonatal HL in the context of the COVID-19 pandemic.
Data were drawn from the COVID-19 Mother Baby Outcomes (COMBO) Initiative. 1007 participants completed the newborn hearing screen as part of routine clinical care (COMBO-EHR cohort) and 555 completed the National Survey of Children's Health (NSCH) at 2 and/or 3 years of age for research purposes (COMBO-RSCH cohort). Maternal SARS-CoV-2 infection status during pregnancy was determined through electronic health records and maternal-reported questionnaires.
In adjusted multivariate logistic regression models covarying for newborn age at assessment, mode of delivery, and gestational age at delivery, there was no significant association between intrauterine SARS-CoV-2 exposure and newborn hearing screening failure (OR = 1.05, 95% CI = 0.39-2.42, p = 0.91) in the COMBO-EHR cohort. In the COMBO-RSCH cohort, there were similar non-significant associations between intrauterine exposure to SARS-CoV-2 and maternal-reported concern for HL on the NSCH (OR = 1.19 [95% CI = 0.30-4.24], p = 0.79).
There is no association between intrauterine exposure to SARS-CoV-2 and failed hearing screen in neonates. Similarly, based on the NSCH, there is no association between intrauterine exposure to SARS-CoV-2 and maternal-reported concern for hearing in toddlers. These results offer reassurance given the widespread nature of this pandemic with tens of millions of fetuses having a history of intrauterine exposure.
4 Laryngoscope, 135:385-392, 2025.
鉴于与宫内病毒暴露相关的新生儿听力损失（HL）的普遍性，本研究的目的是在2019冠状病毒病（COVID-19）大流行的背景下提供有关新生儿HL的信息。
数据来自COVID-19母婴结局（COMBO）倡议。1007名参与者完成了作为常规临床护理一部分的新生儿听力筛查（COMBO-EHR队列），555名参与者在2岁和/或3岁时完成了全国儿童健康调查（NSCH）以用于研究目的（COMBO-RSCH队列）。通过电子健康记录和母亲报告的问卷确定孕期母亲的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染状况。
在对评估时的新生儿年龄、分娩方式和分娩时的胎龄进行协变量调整的多变量逻辑回归模型中，COMBO-EHR队列中宫内SARS-CoV-2暴露与新生儿听力筛查失败之间无显著关联（比值比[OR]=1.05，95%置信区间[CI]=0.39-2.42，p=0.91）。在COMBO-RSCH队列中，宫内SARS-CoV-2暴露与母亲在NSCH上报告的对HL的担忧之间也存在类似的非显著关联（OR=1.19[95%CI=0.30-4.24]，p=0.79）。
宫内SARS-CoV-2暴露与新生儿听力筛查失败之间无关联。同样，基于NSCH，宫内SARS-CoV-2暴露与母亲报告的对幼儿听力的担忧之间也无关联。鉴于这种大流行的广泛性，数以千万计的胎儿有宫内暴露史，这些结果让人安心。
4《喉镜》，135:385-392，2025年。
