母体 COVID-19 与新生儿听力损失：一项多中心调查。
Maternal COVID-19 and neonatal hearing loss: a multicentric survey.
机构信息
Faculty of Medicine, Ain Shams University, 75 El Nozha Street, Heliopolis-Cairo, 11351, Egypt.
Hearing and Speech Institute, Giza, Egypt.
出版信息
Eur Arch Otorhinolaryngol. 2022 Jul;279(7):3435-3438. doi: 10.1007/s00405-021-07098-5. Epub 2021 Oct 2.
PURPOSE
Gestational SARS-Cov-2 infection can impact maternal and neonatal health. The virus has also been reported of causing sensorineural hearing loss. The objective of this study was to determine the possible effect of maternal SARS-COV-2 infection on neonatal hearing as identified during universal hearing screening.
METHODS
Retrospective cohort study in two tertiary referral centers including all neonates born from November 2020 through April 1st, 2021 and undergoing the universal hearing screening program. Maternal Covid-19 infection was recorded (timing and severity) and the results of hearing screening of their neonates compared to the incidence of neonatal hearing loss results of the national universal screening program during the same period.
RESULTS
A total of 984 neonates were included (508 males and 476 females). Sixty-three neonates were excluded due to comorbidities which could cause hearing loss. The incidence of failed responses in the community at large was 2.3%. Twenty-seven failed both steps of screening (2.9%; p < 0.2). There were 34 Covid-19 positive mothers (17 in the first trimester, 8 in the second and 9 in the third). Twenty-nine neonates failed the first screening (p < 0.00001) but on further testing only one neonate failed (2.9%).
CONCLUSION
In this study, neonates born to Covid-19 positive mothers do not seem to have an increased risk of hearing loss. However longer follow-up of these neonates is mandatory to detect any possible delayed effects of the virus.
目的
妊娠感染 SARS-CoV-2 会影响母婴健康。该病毒也被报道可导致感音神经性听力损失。本研究的目的是确定在常规听力筛查中发现的母体 SARS-COV-2 感染对新生儿听力的可能影响。
方法
在两家三级转诊中心进行回顾性队列研究，纳入 2020 年 11 月至 2021 年 4 月 1 日期间出生并接受常规听力筛查的所有新生儿。记录母亲的新冠病毒感染情况（时间和严重程度），并将其新生儿的听力筛查结果与同期全国常规筛查计划的新生儿听力损失发生率进行比较。
结果
共纳入 984 例新生儿（男 508 例，女 476 例）。由于可能导致听力损失的合并症，有 63 例新生儿被排除在外。社区整体失访率为 2.3%。有 27 例新生儿两次筛查均未通过（2.9%；p<0.2）。有 34 例母亲新冠病毒检测阳性（孕早期 17 例，孕中期 8 例，孕晚期 9 例）。29 例新生儿初次筛查未通过（p<0.00001），但进一步检查仅 1 例未通过（2.9%）。
结论
在这项研究中，新冠病毒阳性母亲所生的新生儿似乎没有听力损失风险增加。然而，需要对这些新生儿进行更长时间的随访，以检测病毒可能产生的任何迟发性影响。
Zotero 插件