Shen Guibin, Yang Yongli, Wang Nana, Shi Shangxin, Chen Yongyue, Qiao Ying, Jia Xiaocan, Shi Xuezhong
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, P.R. China.
J Asthma. 2025 Feb;62(2):328-335. doi: 10.1080/02770903.2024.2400613. Epub 2024 Sep 10.
The association of cardiovascular health (CVH) with asthma risk in U.S. adults remains unclear. This study aimed to explore the association of Life's Essential 8 (LE8), a measurement of CVH, with asthma and investigate the potential mediating effect of inflammation and oxidative stress.
The data was obtained from the National Health and Nutrition Examination Survey (NHANES) in 2005-2018. LE8 score (range 0 ∼ 100) was measured and categorized as low (<50), moderate (50 ∼ <80), and high (≥80) CVH. Survey-weighted logistic regression and restricted cubic spline model were employed to explore the association between LE8 score and asthma. Mediation analyses were conducted to identify the mediating effects of inflammation and oxidative stress biomarkers.
This study included 10,932 participants aged ≥ 20 years, among whom 890 (8.14%) reported prevalent asthma. After adjusting for all covariates, the odd ratios (OR) for asthma were 0.67 (95% confidence interval (CI): 0.48, 0.94) in the moderate CVH group and 0.52 (95% CI: 0.34, 0.79) in the high CVH group compared with the low CVH group, respectively. The OR for asthma was 0.85 (95% CI: 0.78, 0.93) for every 10 score increase in LE8 score, and linear dose-response relationship was observed ( 0.0642). Mediation analyses showed that inflammation and oxidative stress mediated 15.97% and 11.50% of the association between LE8 score and asthma, respectively (all < 0.05).
LE8 score was negatively associated with asthma, and inflammation and oxidative stress partially mediated this association. It is recommended that maintaining optimal CVH may prevent asthma.
美国成年人中心血管健康（CVH）与哮喘风险之间的关联尚不清楚。本研究旨在探讨CVH的一种衡量指标——生命基本八项（LE8）与哮喘的关联，并研究炎症和氧化应激的潜在中介作用。
数据来自2005 - 2018年的美国国家健康与营养检查调查（NHANES）。测量LE8评分（范围0至100），并将其分类为低（<50）、中（50至<80）和高（≥80）CVH。采用调查加权逻辑回归和受限立方样条模型来探讨LE8评分与哮喘之间的关联。进行中介分析以确定炎症和氧化应激生物标志物的中介作用。
本研究纳入了10932名年龄≥20岁的参与者，其中890人（8.14%）报告患有哮喘。在调整所有协变量后，与低CVH组相比，中CVH组哮喘的优势比（OR）为0.67（95%置信区间（CI）：0.48，0.94），高CVH组为0.52（95%CI：0.34，0.79）。LE8评分每增加10分，哮喘的OR为0.85（95%CI：0.78，0.93），并观察到线性剂量反应关系（<0.0642）。中介分析表明，炎症和氧化应激分别介导了LE8评分与哮喘之间关联的15.97%和11.50%（均<0.05）。
LE8评分与哮喘呈负相关，炎症和氧化应激部分介导了这种关联。建议维持最佳的CVH可能预防哮喘。
