Liu Xiangliang, Ji Wei, Chang Yu, Li Yuguang, Li Wei, Cui Jiuwei
The First Hospital of Jilin University, Cancer Center, Changchun, China.
The First Hospital of Jilin University, Cancer Center, Changchun, China.
Am J Clin Nutr. 2025 Feb;121(2):436-444. doi: 10.1016/j.ajcnut.2024.11.026. Epub 2024 Nov 28.
Low muscle mass, defined as appendicular lean mass adjusted for body mass index (BMI), may indicate early skeletal muscle deterioration.
This study aimed to investigate the relationship between Life's Essential 8 (LE8), the updated cardiovascular health (CVH) metrics by the American Heart Association, and low muscle mass, including the impact of related biomarkers on muscle quality.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) cycles 2011-2014, selected due to their inclusion of the most recent appendicular lean mass measurements available in the NHANES dataset. Participants aged 20-60 y were included. We employed weighted logistic regression models, restrictive cubic splines, and weighted quantile sum (WQS) regression to assess the relationship between LE8 scores and low muscle mass. Four mediation models were constructed to explore whether serum testosterone in males, serum sex hormone-binding globulin (SHBG) in females, serum albumin, and systemic immune-inflammation index (SII) mediated the association between LE8 scores and low muscle mass.
Higher LE8 scores are associated with lower odds of low muscle mass. Compared with participants with low CVH, those with intermediate and high CVH had 49% (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.30, 0.87) and 86% (OR 0.14, 95% CI: 0.06, 0.29) lower odds of low muscle mass, respectively. Mediation analysis revealed that testosterone, SHBG, SII, and albumin partially mediated the association between LE8 scores and low muscle mass. The WQS regression model indicated that BMI and physical activity might be important factors influencing low muscle mass within the components of LE8.
LE8 scores negatively associated with low muscle mass in United States adults. Serum testosterone in males and SHBG in females were negative predictors of low muscle mass, whereas SII was inversely associated. Serum albumin had a beneficial effect on muscle mass.
低肌肉量定义为根据体重指数（BMI）调整后的四肢瘦体重，可能预示着早期骨骼肌退化。
本研究旨在调查美国心脏协会更新的心血管健康（CVH）指标“生命基本八项（LE8）”与低肌肉量之间的关系，包括相关生物标志物对肌肉质量的影响。
这项横断面研究利用了2011 - 2014年国家健康与营养检查调查（NHANES）周期的数据，选择这些数据是因为它们包含了NHANES数据集中最新的四肢瘦体重测量值。纳入了20 - 60岁的参与者。我们采用加权逻辑回归模型、限制性立方样条和加权分位数和（WQS）回归来评估LE8评分与低肌肉量之间的关系。构建了四个中介模型，以探讨男性血清睾酮、女性血清性激素结合球蛋白（SHBG）、血清白蛋白和全身免疫炎症指数（SII）是否介导了LE8评分与低肌肉量之间的关联。
较高的LE8评分与较低的低肌肉量几率相关。与心血管健康水平低的参与者相比，心血管健康水平中等和高的参与者低肌肉量几率分别低49%（优势比[OR]：0.51，95%置信区间[CI]：0.30，0.87）和86%（OR 0.14，95% CI：0.06，0.29）。中介分析表明，睾酮、SHBG、SII和白蛋白部分介导了LE8评分与低肌肉量之间的关联。WQS回归模型表明，BMI和身体活动可能是LE8各组成部分中影响低肌肉量的重要因素。
在美国成年人中，LE8评分与低肌肉量呈负相关。男性血清睾酮和女性SHBG是低肌肉量的负向预测指标，而SII与之呈负相关。血清白蛋白对肌肉量有有益影响。
