Vandenbark A A, De Saedeleer J, Heyligen H, Dom R, Raus J, Stragier J, Carton H
J Neuroimmunol. 1985 May;8(2-3):103-14. doi: 10.1016/s0165-5728(85)80051-5.
Inflammatory conditions of the central nervous system (CNS) are often marked by an increase in lymphocyte number in the cerebrospinal fluid (CSF). In order to determine if changes in CSF cell numbers can alter T-lymphocyte subset composition in CSF or in blood, cell surface markers were evaluated in 25 CSF and paired blood samples from a variety of neurologically affected patients. T-cell subset levels in peripheral blood did not reflect subset levels in paired CSF samples. However, CSF samples with elevated cell numbers (greater than 3 cells/mm3) had significantly increased levels of Leu-3+ T-cells (P less than 0.001), but not Leu-2+ T-cells relative to CSF samples with low cell counts. These data suggest a selective increase in the Leu-3+ T-lymphocyte subset in CSFs with increased cellularity in patients with acute neurologic signs.
中枢神经系统（CNS）的炎症性疾病通常以脑脊液（CSF）中淋巴细胞数量增加为特征。为了确定CSF细胞数量的变化是否会改变CSF或血液中的T淋巴细胞亚群组成，对25例来自各种神经系统疾病患者的CSF及配对血液样本中的细胞表面标志物进行了评估。外周血中的T细胞亚群水平并不能反映配对CSF样本中的亚群水平。然而，相对于细胞计数低的CSF样本，细胞数量升高（大于3个细胞/mm³）的CSF样本中Leu-3⁺ T细胞水平显著升高（P小于0.001），但Leu-2⁺ T细胞水平并未升高。这些数据表明，在有急性神经症状的患者中，细胞增多的CSF中Leu-3⁺ T淋巴细胞亚群有选择性增加。
