多发性硬化症及其他神经疾病患者脑脊液细胞上的白细胞介素-2受体和人类白细胞抗原II类抗原
IL-2 receptor and HLA class II antigens on cerebrospinal fluid cells of patients with multiple sclerosis and other neurological diseases.
作者信息
Tournier-Lasserve E, Lyoncaen O, Roullet E, Bach M A
出版信息
Clin Exp Immunol. 1987 Mar;67(3):581-6.
Abstract
The presence of IL-2 receptor and HLA class II antigens as detected by monoclonal antibodies on mononuclear cells from both cerebro-spinal fluid (CSF) and peripheral blood was examined by cytofluorographic analysis in patients with multiple sclerosis (MS) and other neurological diseases. CSF as compared to blood was enriched in cells expressing IL-2 receptor and HLA class II molecules both in MS patients and in other inflammatory diseases of the central nervous system suggesting that activated T-cells concentrate within the central nervous system.
摘要
通过细胞荧光分析检测了多发性硬化症（MS）患者和其他神经系统疾病患者脑脊液（CSF）及外周血单个核细胞上由单克隆抗体检测到的IL-2受体和HLA-II类抗原的存在情况。与血液相比，无论是MS患者还是中枢神经系统的其他炎症性疾病患者，脑脊液中表达IL-2受体和HLA-II类分子的细胞均有所富集，这表明活化的T细胞集中在中枢神经系统内。
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