He Qiang, Mei Jie, Xie Chengxin, Wang Zhen, Sun Xin, Xu Mengmeng
Department of Orthopedic, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China.
Department of Orthopedic, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, China.
J Am Nutr Assoc. 2025 Jan;44(1):29-39. doi: 10.1080/27697061.2024.2389398. Epub 2024 Sep 4.
This study aims to investigate the association between central obesity and the risk of osteoarthritis, and the mediating role of biological age and biological aging advance in this relationship.
The study is based on data from the National Health and Nutrition Examination Survey (NHANES) for the years 2005-2018. Thirteen commonly used clinical traits were used to calculate the Klemera-Doubal method age (KDM-Age) and phenotypic age (Pheno-Age) as two measures of biological aging. Additionally, KDM-Age advance and Pheno-Age advance were calculated as two measures of biological aging advance. Weighted multivariable logistic regression was used to analyze the association between central obesity and the risk of osteoarthritis (OA). Mediation analysis was then applied to elucidate the role of biological aging and biological aging advance in this relationship.
A total of 31,162 subjects aged ≥20 years were included in this study, of which 3,964 subjects reported having OA (14%). Compared to the Non-OA group, the OA group showed significantly higher proportions of central obesity, KDM-Age, KDM-Age advance, PhenoAge, and PhenoAge advance. Compared to the Non-central obesity group, the central obesity group had higher KDM-Age, KDM-Age advance, PhenoAge, PhenoAge advance, and a higher risk of OA ( < 0.05). Additionally, higher KDM-Age, KDM-Age advance, PhenoAge, and PhenoAge advance were positively correlated with the risk of OA ( < 0.05). Mediation analysis revealed that part of the association between central obesity and the risk of OA was mediated by KDM-Age, KDM-Age advance, PhenoAge, and PhenoAge advance ( < 0.05).
Central obesity increases the risk of OA, with part of this association being mediated by biological aging and biological aging advance.
本研究旨在探讨中心性肥胖与骨关节炎风险之间的关联，以及生物学年龄和生物学衰老进展在这种关系中的中介作用。
本研究基于2005 - 2018年美国国家健康与营养检查调查（NHANES）的数据。使用13种常用的临床特征来计算克莱梅拉 - 杜巴尔法年龄（KDM - 年龄）和表型年龄（Pheno - 年龄），作为生物学衰老的两种衡量指标。此外，计算KDM - 年龄进展和表型年龄进展作为生物学衰老进展的两种衡量指标。采用加权多变量逻辑回归分析中心性肥胖与骨关节炎（OA）风险之间的关联。然后应用中介分析来阐明生物学衰老和生物学衰老进展在这种关系中的作用。
本研究共纳入31162名年龄≥20岁的受试者，其中3964名受试者报告患有OA（14%）。与非OA组相比，OA组的中心性肥胖、KDM - 年龄、KDM - 年龄进展、表型年龄和表型年龄进展的比例显著更高。与非中心性肥胖组相比，中心性肥胖组的KDM - 年龄、KDM - 年龄进展、表型年龄、表型年龄进展更高，且OA风险更高（<0.05）。此外，较高的KDM - 年龄、KDM - 年龄进展、表型年龄和表型年龄进展与OA风险呈正相关（<0.05）。中介分析显示，中心性肥胖与OA风险之间的部分关联由KDM - 年龄、KDM - 年龄进展、表型年龄和表型年龄进展介导（<0.05）。
中心性肥胖会增加OA风险，这种关联部分由生物学衰老和生物学衰老进展介导。
