白细胞介素-6 与缺血性脑卒中复发。
IL-6 and stroke recurrence in ischemic stroke.
机构信息
Spine Center, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
出版信息
Biomark Med. 2024;18(17-18):739-747. doi: 10.1080/17520363.2024.2389038. Epub 2024 Sep 4.
Abstract
This study aimed to evaluate the predictive value of IL-6 for stroke recurrence in acute ischemic stroke. Patients who were admitted within 48 h of onset were included. At 3-month, stroke recurrence was assessed. IL-6 levels were measured in serum samples taken upon admission. Out of the 305 patients, 47 (15.4%) experienced a stroke recurrence. The risk of stroke recurrence increased by 8% (OR: 1.08; 95% CI: 1.04-1.11; < 0.001) for every 1 pg/ml increase in IL-6 serum level, both in unadjusted and adjusted analyses (6%; OR: 1.06; 95% CI: 1.02-1.10; = 0.001). The study supports the usefulness of IL-6 as a predictive biomarker for stroke recurrence after acute ischemic stroke.
摘要
这项研究旨在评估 IL-6 对急性缺血性脑卒中患者卒中复发的预测价值。纳入发病后 48 小时内入院的患者。在 3 个月时评估卒中复发情况。在入院时采集的血清样本中测量 IL-6 水平。在 305 名患者中，47 名（15.4%）发生卒中复发。在未调整和调整分析中，IL-6 血清水平每增加 1pg/ml，卒中复发的风险增加 8%（OR：1.08；95%CI：1.04-1.11；<0.001）（6%；OR：1.06；95%CI：1.02-1.10；=0.001）。该研究支持 IL-6 作为急性缺血性脑卒中后卒中复发的预测生物标志物的有用性。
相似文献
1
IL-6 and stroke recurrence in ischemic stroke.白细胞介素-6 与缺血性脑卒中复发。
Biomark Med. 2024;18(17-18):739-747. doi: 10.1080/17520363.2024.2389038. Epub 2024 Sep 4.
2
Clinical and Radiological Evaluation of Severity of Acute Ischemic Stroke with Special Reference to Neuroinflammatory Biomarkers.急性缺血性卒中严重程度的临床与影像学评估：特别关注神经炎症生物标志物
Ann Afr Med. 2025 Jul 1;24(3):567-572. doi: 10.4103/aam.aam_78_24. Epub 2025 Apr 1.
3
Rapid Diagnosis of Intracerebral Hemorrhage in Patients With Acute Stroke by Measuring Prehospital GFAP Levels on a Point-of-Care Device (DETECT).通过即时检测设备（DETECT）测量院前GFAP水平对急性卒中患者进行脑出血的快速诊断。
Neurology. 2025 Jul 22;105(2):e213823. doi: 10.1212/WNL.0000000000213823. Epub 2025 Jun 26.
4
Predictive value of interleukin-6 combined with serum neuron-specific enolase on the prognosis of acute ischemic stroke.白细胞介素-6 联合血清神经元特异性烯醇化酶对急性缺血性脑卒中预后的预测价值。
Clin Neurol Neurosurg. 2024 Sep;244:108406. doi: 10.1016/j.clineuro.2024.108406. Epub 2024 Jun 24.
5
Interleukin-6, C-Reactive Protein, and Recurrence After Stroke: A Time-Course Analysis of Individual-Participant Data.白细胞介素-6、C 反应蛋白与卒中后复发：一项个体参与者数据的时间进程分析。
Stroke. 2024 Dec;55(12):2825-2834. doi: 10.1161/STROKEAHA.124.047820. Epub 2024 Oct 31.
6
Interleukin-6, C-Reactive Protein, and Vascular Recurrence After Stroke With and Without Atherosclerosis.伴或不伴动脉粥样硬化性卒中后的白细胞介素-6、C反应蛋白与血管复发
Stroke. 2025 Sep;56(9):2588-2596. doi: 10.1161/STROKEAHA.125.052091. Epub 2025 Jul 18.
7
Plasma Phenylacetylglutamine Levels and Prognosis of Ischemic Stroke: A Multicenter Prospective Study Based on the CATIS Trial.基于 CATIS 试验的多中心前瞻性研究：血浆苯乙酰谷氨酰胺水平与缺血性脑卒中预后的关系。
Stroke. 2024 Nov;55(11):2652-2660. doi: 10.1161/STROKEAHA.124.048494. Epub 2024 Oct 28.
8
Tryptophan metabolites as biomarkers to predict the severity and prognosis of acute ischemic stroke patients.色氨酸代谢产物作为预测急性缺血性中风患者严重程度和预后的生物标志物。
J Stroke Cerebrovasc Dis. 2025 Aug;34(8):108382. doi: 10.1016/j.jstrokecerebrovasdis.2025.108382. Epub 2025 Jun 17.
9
Role of NT-proBNP for Atrial Fibrillation Detection After Ischemic Stroke: A Time-Dependent Relationship.N末端B型利钠肽原在缺血性卒中后房颤检测中的作用：一种时间依赖性关系。
Stroke. 2025 Jul;56(7):1704-1713. doi: 10.1161/STROKEAHA.124.049249. Epub 2025 Apr 21.
10
Predictive value of glycoprotein DKK3 for early neurological deterioration after ischemic stroke.糖蛋白DKK3对缺血性中风后早期神经功能恶化的预测价值。
Clinics (Sao Paulo). 2024 Apr 27;79:100360. doi: 10.1016/j.clinsp.2024.100360. eCollection 2024.
引用本文的文献
1
The Role of IL-6 in Ischemic Stroke.白细胞介素-6在缺血性卒中中的作用。
Biomolecules. 2025 Mar 23;15(4):470. doi: 10.3390/biom15040470.
2
Molecular Links and Clinical Effects of Inflammation and Metabolic Background on Ischemic Stroke: An Update Review.炎症和代谢背景对缺血性中风的分子联系及临床影响：最新综述
J Clin Med. 2024 Dec 10;13(24):7515. doi: 10.3390/jcm13247515.
本文引用的文献
1
C-Reactive Protein, Interleukin-6, and Vascular Recurrence According to Stroke Subtype: An Individual Participant Data Meta-Analysis.C-反应蛋白、白细胞介素-6 与血管性复发的相关性：一项基于个体参与者数据的荟萃分析。
Neurology. 2024 Jan 23;102(2):e208016. doi: 10.1212/WNL.0000000000208016. Epub 2023 Dec 19.
2
Targeting inflammation to reduce recurrent stroke.针对炎症以减少复发性中风。
Int J Stroke. 2024 Apr;19(4):379-387. doi: 10.1177/17474930231207777. Epub 2023 Oct 19.
3
C-Reactive Protein, Interleukin-6, and Vascular Recurrence After Stroke: An Individual Participant Data Meta-Analysis.C-反应蛋白、白细胞介素-6 与卒中后血管再发事件：一项个体参与者数据的荟萃分析。
Stroke. 2023 May;54(5):1289-1299. doi: 10.1161/STROKEAHA.122.040529. Epub 2023 Apr 7.
4
Estimated Burden of Stroke in China in 2020.2020 年中国脑卒中发病与死亡负担估计。
JAMA Netw Open. 2023 Mar 1;6(3):e231455. doi: 10.1001/jamanetworkopen.2023.1455.
5
Interleukin-6, C-reactive protein, fibrinogen, and risk of recurrence after ischaemic stroke: Systematic review and meta-analysis.白细胞介素-6、C反应蛋白、纤维蛋白原与缺血性中风复发风险：系统评价与荟萃分析
Eur Stroke J. 2021 Mar;6(1):62-71. doi: 10.1177/2396987320984003. Epub 2021 Jan 5.
6
A case series of ischemic stroke with coronavirus disease 2019 in two Egyptian centers.埃及两个中心的2019冠状病毒病合并缺血性中风病例系列
Egypt J Neurol Psychiatr Neurosurg. 2020;56(1):120. doi: 10.1186/s41983-020-00259-z. Epub 2020 Dec 24.
7
Elevated levels of adiponectin associated with major adverse cardiovascular and cerebrovascular events and mortality risk in ischemic stroke.脂联素水平升高与缺血性脑卒中主要不良心脑血管事件及死亡风险相关。
Cardiovasc Diabetol. 2020 Aug 8;19(1):125. doi: 10.1186/s12933-020-01096-3.
8
Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study.白细胞介素-6信号传导对缺血性中风及其他心血管结局的影响：一项孟德尔随机化研究
Circ Genom Precis Med. 2020 Jun;13(3):e002872. doi: 10.1161/CIRCGEN.119.002872. Epub 2020 May 12.
9
Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study.中国 2018 年美国糖尿病协会诊断标准下的中国大陆糖尿病患病率：全国横断面研究。
BMJ. 2020 Apr 28;369:m997. doi: 10.1136/bmj.m997.
10
Serum β2-Microglobulin Is Closely Associated With the Recurrence Risk and 3-Month Outcome of Acute Ischemic Stroke.血清β2-微球蛋白与急性缺血性卒中的复发风险及3个月预后密切相关。
Front Neurol. 2020 Jan 9;10:1334. doi: 10.3389/fneur.2019.01334. eCollection 2019.
Zotero 插件