Pacinella Gaetano, Ciaccio Anna Maria, Tuttolomondo Antonino
Internal Medicine and Stroke Care Ward, Department of Promoting Health, Maternal-Infant, Excellence and Internal and Specialized Medicine (PROMISE), University of Palermo, 90127 Palermo, Italy.
J Clin Med. 2024 Dec 10;13(24):7515. doi: 10.3390/jcm13247515.
Stroke is a major global health concern, with 12.2 million new cases and 6.6 million deaths reported in 2019, making it the second leading cause of death and third leading cause of disability worldwide. Ischemic stroke, caused by blood vessel occlusion, accounts for 87% of stroke cases and results in neuronal death due to oxygen and nutrient deprivation. The rising global stroke burden is linked to aging populations and increased metabolic risk factors like high blood pressure, obesity, and elevated glucose levels, which promote chronic inflammation. This article explores the intricate molecular and clinical interplay between inflammation and metabolic disorders, emphasizing their role in ischemic stroke development, progression, and outcomes.
中风是一个重大的全球健康问题，2019年报告有1220万新发病例和660万人死亡，使其成为全球第二大死因和第三大致残原因。由血管闭塞引起的缺血性中风占中风病例的87%，并由于氧气和营养物质缺乏导致神经元死亡。全球中风负担的增加与人口老龄化以及高血压、肥胖和血糖升高等代谢风险因素增加有关，这些因素会促进慢性炎症。本文探讨炎症与代谢紊乱之间复杂的分子和临床相互作用，强调它们在缺血性中风发生、发展和结局中的作用。
