Department of General Surgery, Polatlı Duatepe State Hospital, Polatlı, Ankara, Turkey.
Department of General Surgery, Gölbaşı Şehit Ahmet Özsoy State Hospital, Gölbaş, Ankara, Turkey.
Clin Exp Med. 2024 Sep 4;24(1):211. doi: 10.1007/s10238-024-01480-3.
Colorectal cancer (CRC) is a major health problem worldwide and is usually detected in advanced stages, although it is highly treatable with early detection. The aim of this study was to examine the serum levels of various cytokines involved in the pathogenesis of CRC. The study included 29 patients and 30 healthy volunteers. Blood samples were collected twice from the patient group, before and after surgery, and these samples were evaluated for interleukin (IL) 4, 10, 23r, 37, 38, 40 and interferon (IFN) gamma levels. The results showed that IL-4 and IL-38 levels were significantly lower in the preoperative serum samples of the patient group compared to the control group (p < 0.001 and p = 0.01, respectively), while IL-4, IL-10, IL-38 and IL-40 levels increased significantly in the postoperative period (p = 0.004, p = 0.02, p = 0.03 and p = 0.004, respectively). These findings may contribute to the development of immunotherapy agents in the treatment of CRC. However, comprehensive studies on larger patient groups are needed to fully understand the role of cytokines in CRC pathogenesis.
结直肠癌（CRC）是全球范围内的一个主要健康问题，尽管早期发现高度可治疗，但通常在晚期才被检测到。本研究旨在研究参与 CRC 发病机制的各种细胞因子的血清水平。该研究包括 29 名患者和 30 名健康志愿者。从患者组采集了两次血样，手术前后，并对白细胞介素（IL）4、10、23r、37、38、40 和干扰素（IFN）γ水平进行了评估。结果表明，与对照组相比，患者组术前血清样本中的 IL-4 和 IL-38 水平显着降低（p < 0.001 和 p = 0.01），而术后 IL-4、IL-10、IL-38 和 IL-40 水平显着升高（p = 0.004，p = 0.02，p = 0.03 和 p = 0.004）。这些发现可能有助于开发 CRC 治疗中的免疫治疗剂。然而，需要对更大的患者组进行综合研究，以充分了解细胞因子在 CRC 发病机制中的作用。
