J Drugs Dermatol. 2024 Sep 1;23(9):769-773. doi: 10.36849/JDD.8309.
Acne can cause disfiguring sequelae, such as scarring, post-inflammatory erythema (PIE), and post-inflammatory hyperpigmentation (PIH). These post-inflammatory dyschromias pose a significant psychological burden on patients. This burden disproportionately affects skin of color (SOC) patients and can be the most distressing aspect of acne in SOC patients with skin types IV to VI. Multiple non-ablative lasers are used in the treatment of acne-related PIE and PIH. Combination therapies have shown promise in conditions such as rosacea, acne, and post-inflammatory dyschromia. Addressing both the inflammatory and scarring components of acne is key. Given the role of oxidation in the inflammatory cascade, including antioxidants could be an efficacious adjuvant with non-ablative lasers. This is a single-site, randomized, controlled clinical study of 25 subjects with skin types I to VI with facial PIE and/or PIH from acne. The primary objective was to investigate the clinical efficacy of non-ablative laser therapy followed by the topical application of Silymarin/Salicylic Acid/L-Ascorbic Acid/Ferulic Acid (SSAF) or control in the improvement in oily skin patients with facial PIE and PIH due to acne lesions. There was a statistically significant decrease in PIH and intralesional melanin in patients treated with a combination SSAF and non-ablative laser therapy. Improvement of both PIE and PIH was augmented in combination with SSAF and laser-treated patients compared with the laser-only group, with a concomitant increase in collagen density. This was even more strikingly marked in the SOC subjects, potentially providing an energy-based device (EBD)-based therapy in this population. Limitations of this study include small sample size and length of post-treatment follow-up. J Drugs Dermatol. 2024;23(9):769-773. doi:10.36849/JDD.8309.
痤疮可导致毁容性后遗症，如瘢痕、炎症后红斑（PIE）和炎症后色素沉着过度（PIH）。这些炎症后色素紊乱给患者带来了巨大的心理负担。这种负担不成比例地影响到有色人种（SOC）患者，并且可能是 SOC 患者（皮肤类型为 IV 至 VI 型）痤疮中最令人痛苦的方面。多种非剥脱性激光被用于治疗与痤疮相关的 PIE 和 PIH。联合疗法在玫瑰痤疮、痤疮和炎症后色素紊乱等疾病中显示出了良好的效果。解决痤疮的炎症和瘢痕成分是关键。鉴于氧化在炎症级联反应中的作用，包括抗氧化剂在内的治疗方法可能是一种有效的非剥脱性激光辅助治疗方法。这是一项单中心、随机、对照的临床研究，纳入了 25 名皮肤类型为 I 至 VI 型的痤疮患者，他们有面部 PIE 和/或 PIH。主要目的是研究非剥脱性激光治疗后外用水飞蓟素/水杨酸/L-抗坏血酸/阿魏酸（SSAF）或对照剂治疗痤疮性面部 PIE 和 PIH 患者的临床疗效。联合 SSAF 和非剥脱性激光治疗的患者 PIH 和皮损内黑色素均有统计学显著下降。与单独激光治疗组相比，联合 SSAF 和激光治疗的患者 PIE 和 PIH 均得到改善，同时胶原密度增加。在 SOC 患者中更为显著，这可能为该人群提供一种基于能量的治疗方法。本研究的局限性包括样本量小和治疗后随访时间短。J 皮肤病药物杂志。2024;23(9):769-773.doi:10.36849/JDD.8309.
