Department of Dermatology, Keck School of Medicine, University of Southern California, 830 S Flower Street, Suite 100, Los Angeles, CA, 90017, USA.
Department of Dermatology, David Geffen School of Medicine, University of California - Los Angeles, CA, Los Angeles, USA.
Am J Clin Dermatol. 2021 Nov;22(6):829-836. doi: 10.1007/s40257-021-00633-4. Epub 2021 Sep 1.
Acne vulgaris is a common inflammatory disease. Among patients with darker skin phototypes (Fitzpatrick III-VI), the inflammatory processes of acne stimulate excess melanogenesis and abnormal melanin deposition, leading to pigmentary sequelae known as post-inflammatory hyperpigmentation and post-inflammatory erythema in all skin tones, although post-inflammatory hyperpigmentation is more common in darker skin and post-inflammatory erythema in lighter skin. These pigmentary alterations can be long lasting and are often more distressing to patients than the active acne lesions. This article discusses what is known about acne-related pigmentation, much of which is extrapolated from general study of nonspecific pigment deposition. Because dyspigmentation poses both a significant clinical concern to patients and a therapeutic challenge to clinicians, we formed a working group consisting of pigmentary experts with the aim of increasing awareness and education of acne-related pigmentary sequelae.
寻常痤疮是一种常见的炎症性疾病。在肤色较深的患者中(Fitzpatrick 三至六型),痤疮的炎症过程会刺激黑色素生成过多和异常黑色素沉积,导致所有肤色的炎症后色素沉着和炎症后红斑等色素沉着后遗症,尽管炎症后色素沉着在肤色较深的人中更为常见,炎症后红斑在肤色较浅的人中更为常见。这些色素改变可能持久存在,并且往往比活动期痤疮皮损更令患者苦恼。本文讨论了与痤疮相关的色素沉着问题,其中大部分是从非特异性色素沉着的一般研究中推断出来的。由于色素沉着异常不仅对患者具有重要的临床意义,而且对临床医生也是一个治疗挑战,因此我们成立了一个由色素沉着专家组成的工作组,旨在提高对痤疮相关色素沉着后遗症的认识和教育。