Kurihara K, Hashimoto N
J Oral Pathol. 1985 Apr;14(4):289-98. doi: 10.1111/j.1600-0714.1985.tb00496.x.
The functional role of Langerhans cells (LCs) in oral cancer was studied, based on a quantitative analysis of LCs in squamous cell carcinomas arising from the tongue. LCs were identified by their positiveness for S100-protein and other cytological characters based on PAP method. LCs increased in number in the cancer region and showed an intimate relationship with lymphocytes in terms of their number and distribution. Moreover, in those cases with many LCs, clusters consisting of LCs and lymphocytes were often found to combine into "hydropic degeneration-like" lesions as seen in allergic disease such as dermal lichen planus. These findings, as well as the review of literature, suggested some immunological role of LCs in oral carcinoma.
基于对舌部鳞状细胞癌中朗格汉斯细胞（LCs）的定量分析，研究了LCs在口腔癌中的功能作用。采用PAP法，根据S100蛋白阳性及其他细胞学特征鉴定LCs。癌区LCs数量增加，且在数量和分布方面与淋巴细胞关系密切。此外，在LCs数量较多的病例中，常发现由LCs和淋巴细胞组成的簇融合形成“水样变性样”病变，如皮肤扁平苔藓等过敏性疾病所见。这些发现以及文献回顾提示LCs在口腔癌中具有一定的免疫作用。
