Department of Ophthalmology, Dokuz Eylul University, İzmir, Turkey.
Buca Seyfi Demirsoy Training and Research Hospital, Department of Ophthalmology, İzmir Democracy University, Kozağaç Mah., Özmen Sok., No:147, Buca, İzmir, Turkey.
Int Ophthalmol. 2024 Sep 4;44(1):365. doi: 10.1007/s10792-024-03294-4.
This study aims to assess the disparities in choroidal thickness and optic disc parameters between individuals diagnosed with chronic gout and an age- and gender-matched control cohort.
This cross-sectional study involved 30 gout patients receiving treatment at the Rheumatology clinic, alongside 30 healthy control individuals matched for age and gender. A comprehensive ophthalmological assessment, encompassing visual acuity measurement, intraocular pressure evaluation, slit-lamp biomicroscopy, and dilated fundus examination, was conducted for all participants. Peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and subfoveal choroidal thickness (SFCT) were quantified utilizing Spectral Domain Optical Coherence Tomography.
The mean age within the study group was 54.53 ± 9.43 years, while the control group's mean age was 53.20 ± 10.36 years. In both the gout and control cohorts, there were 28 men and 2 women. No significant differences were observed in age and gender between the groups. Gout patients manifested thinner RNFL and GCC across all quadrants; however, statistically significant thinning was only evident in the nasal and inferior quadrants for RNFL. Despite a thinner SFCT observed in gout patients compared to controls, this discrepancy did not attain statistical significance.
Chronic phase gout patients may display alterations in optic disc and macular parameters, alongside potential variations in choroidal thickness. Nevertheless, more controlled studies encompassing a larger participant pool are imperative to substantiate our findings.
本研究旨在评估慢性痛风患者与年龄和性别相匹配的对照组之间脉络膜厚度和视盘参数的差异。
这项横断面研究纳入了 30 名在风湿病诊所接受治疗的痛风患者，以及 30 名年龄和性别相匹配的健康对照者。所有参与者均接受全面的眼科评估，包括视力测量、眼压评估、裂隙灯生物显微镜检查和散瞳眼底检查。利用频域光相干断层扫描（Spectral Domain Optical Coherence Tomography）定量测量视盘周围视网膜神经纤维层（Retinal Nerve Fiber Layer，RNFL）、神经节细胞复合体（Ganglion Cell Complex，GCC）和中心凹下脉络膜厚度（Subfoveal Choroidal Thickness，SFCT）。
研究组的平均年龄为 54.53±9.43 岁，对照组的平均年龄为 53.20±10.36 岁。两组中均有 28 名男性和 2 名女性。两组在年龄和性别方面无显著差异。痛风患者的所有象限的 RNFL 和 GCC 均较薄；然而，只有在鼻侧和下方象限，RNFL 的变薄具有统计学意义。尽管与对照组相比，痛风患者的 SFCT 较薄，但差异无统计学意义。
慢性痛风患者可能会出现视盘和黄斑参数的改变，以及脉络膜厚度的潜在变化。然而，需要更多包含更大样本量的对照研究来证实我们的发现。
