Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, 28359, Bremen, Germany.
GENUD (Growth, Exercise, Nutrition and Development) Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria de Aragón (IIS Aragón), University of Zaragoza, Saragossa, Spain.
Eur J Nutr. 2024 Dec;63(8):3047-3060. doi: 10.1007/s00394-024-03488-7. Epub 2024 Sep 4.
To investigate longitudinal associations between the vitamin D status and inflammatory markers in children and adolescents.
Children from eight European countries from the IDEFICS/I.Family cohort with repeated measurements were included in this study. A linear mixed-effect model was used to model the association of serum 25(OH)D as independent variable and z-scores of inflammatory markers [CRP, cytokines, adipokines, combined inflammation score] as dependent variables, where one level accounts for differences between individuals and the other for changes over age within individuals.
A total of 1,582 children were included in the study. In the adjusted model, 25(OH)D levels were positively associated with adiponectin (β = 0.11 [95% CI 0.07; 0.16]) and negatively with the inflammation score (β = - 0.24 [95% CI - 0.40; - 0.08]) indicating that the adiponectin z-score increased by 0.11 units and the inflammation score decreased by 0.24 units per 12.5 nmol/l increase in 25(OH)D. In children with overweight or obesity, only a positive association between 25(OH)D and IP-10 was observed while in children with normal weight adiponectin was positively and the inflammation score was negatively associated. Associations of vitamin D with adiponectin and the inflammation score were stronger in girls than in boys and a positive association with TNF-α was observed only in girls.
Our results suggest that an increase in vitamin D concentrations may help to regulate inflammatory biomarkers. However, it seems to be no benefit of a better vitamin D status in children with overweight/obesity unless their weight is managed to achieve an improved inflammatory marker status.
研究儿童和青少年维生素 D 状况与炎症标志物之间的纵向关联。
本研究纳入了来自 IDEFICS/I.Family 队列的来自 8 个欧洲国家的重复测量儿童。采用线性混合效应模型，将血清 25(OH)D 作为自变量，炎症标志物（CRP、细胞因子、脂肪因子、综合炎症评分）的 z 分数作为因变量，其中一个水平代表个体之间的差异，另一个水平代表个体内部随年龄的变化。
共纳入 1582 名儿童。在调整后的模型中，25(OH)D 水平与脂联素呈正相关（β=0.11 [95%CI 0.07; 0.16]），与炎症评分呈负相关（β=−0.24 [95%CI−0.40;−0.08]），表明脂联素 z 分数增加 0.11 单位，炎症评分每增加 12.5 nmol/l 25(OH)D 降低 0.24 单位。在超重或肥胖的儿童中，仅观察到 25(OH)D 与 IP-10 之间存在正相关，而在体重正常的儿童中，脂联素呈正相关，炎症评分呈负相关。维生素 D 与脂联素和炎症评分的关联在女孩中比在男孩中更强，并且仅在女孩中观察到与 TNF-α 的正相关。
我们的研究结果表明，增加维生素 D 浓度可能有助于调节炎症生物标志物。然而，除非超重/肥胖儿童的体重得到管理以改善炎症标志物状态，否则改善维生素 D 状况对他们没有益处。
