COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.
Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, 2300 Copenhagen, Denmark.
Nutrients. 2021 Dec 21;14(1):15. doi: 10.3390/nu14010015.
Vitamin D deficiency and elevated high sensitivity C-reactive protein (hs-CRP) have been associated with several health outcomes, but knowledge on early life trajectories and association between 25 hydroxyvitamin D (25(OH)D) and hs-CRP is lacking. We investigated the association between longitudinal measurements of 25(OH)D and hs-CRP, respectively, from pregnancy to childhood and throughout childhood in two Danish mother-child cohorts-the COPSAC and COPSAC. In COPSAC, there was an association between 25(OH)D concentrations at week 24 in pregnancy and at age 6 months in childhood ( 633): estimate (95% CI); 0.114 (0.041;0.187), 0.002, and between 25(OH)D at age 6 months and 6 years ( 475): 0.155 (0.083;0.228), 0.001. This was also demonstrated in the COPSAC cohort between 25(OH)D concentrations in cord blood and at age 4 years ( 188): 0.294 (0.127;0.461), 0.001 and at age 6 months and 4 years ( 264): 0.260 (0.133;0.388), 0.001. In COPSAC, we also found an association between hs-CRP at age 6 months and 12 years in childhood ( 232): 0.183 (0.076;0.289), 0.001. Finally, we found a negative association between the cross-sectional measurements of 25(OH)D and hs-CRP at age 6 months ( 613) in COPSAC: -0.004 (-0.008;-0.0004), 0.030, but this was not replicated in COPSAC. In this study, we found evidence of associations across timepoints of 25(OH)D concentrations from mid-pregnancy to infancy and through childhood and associations between hs-CRP levels during childhood, although with weak correlations. We also found a negative cross-sectional association between 25(OH)D and hs-CRP concentrations in COPSAC proposing a role of vitamin D in systemic low-grade inflammation, though this association was not present in COPSAC.
维生素 D 缺乏症和高敏 C 反应蛋白（hs-CRP）升高与多种健康结果有关，但人们对 25 羟维生素 D（25（OH）D）和 hs-CRP 的早期生命轨迹和关联知之甚少。我们在两个丹麦母婴队列（COPSAC 和 COPSAC）中分别研究了从妊娠到儿童期以及整个儿童期 25（OH）D 和 hs-CRP 的纵向测量之间的关联。在 COPSAC 中，妊娠第 24 周和儿童期 6 个月时的 25（OH）D 浓度之间存在关联（633）：估计值（95%CI）；0.114（0.041；0.187），0.002，以及 6 个月和 6 岁时的 25（OH）D 之间的关联（475）：0.155（0.083；0.228），0.001。这在 COPSAC 队列中也得到了证实，脐带血和 4 岁时的 25（OH）D 浓度之间存在关联（188）：0.294（0.127；0.461），0.001，以及 6 个月和 4 岁时的 25（OH）D 浓度之间存在关联（264）：0.260（0.133；0.388），0.001。在 COPSAC 中，我们还发现儿童期 6 个月和 12 岁时 hs-CRP 之间存在关联（232）：0.183（0.076；0.289），0.001。最后，我们发现 COPSAC 中 6 个月时 25（OH）D 和 hs-CRP 的横断面测量之间存在负相关（613）：-0.004（-0.008；-0.0004），0.030，但在 COPSAC 中并未得到复制。在这项研究中，我们发现了从妊娠中期到婴儿期以及整个儿童期的 25（OH）D 浓度的时间点之间的关联以及儿童期 hs-CRP 水平之间的关联，尽管相关性较弱。我们还发现 COPSAC 中 25（OH）D 和 hs-CRP 浓度之间存在负横断面关联，表明维生素 D 在全身低度炎症中起作用，但在 COPSAC 中不存在这种关联。
