Zeeb Hajo, Brand Tilman, Lissner Lauren, Lauria Fabio, Molnár Dénes, Veidebaum Toomas, Nauck Matthias, Tornaritis Michael, De Henauw Stefaan, Moreno Luis A, Ahrens Wolfgang, Pohlabeln Hermann, Wolters Maike
Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, 28359, Bremen, Germany.
Human and Health Sciences, University of Bremen, Bremen, Germany.
Eur J Pediatr. 2025 Feb 11;184(2):190. doi: 10.1007/s00431-025-06024-9.
This aimed to investigate associations between the vitamin D status and handgrip strength in children and adolescents considering weight status. Participants aged 7 to < 16 years from the European IDEFICS/I.Family cohort were included. Serum 25-hydroxyvitamin D [25(OH)D] and handgrip strength were measured in 2013/2014. In multivariable logistic regression models, we investigated the association of vitamin D status with handgrip strength adjusted for demographic variables, BMI z-score, sports club membership, screen time and UV intensity. Vitamin D-sufficient children had higher odds for a high handgrip strength (OR = 1.92, 95%-CI: 1.12, 3.30), but this association was limited to children with thinness/normal weight (OR = 2.60, 95%-CI: 1.41-4.81). Children with overweight (OR = 2.64, 95%-CI: 2.00, 3.49) and obesity (OR = 4.53, 95%-CI: 2.93, 7.02) were more likely to have a high handgrip strength than thin/normal weight children.
The positive association of vitamin D with muscle strength in our study is limited to children with low and normal BMI. In children with overweight or obesity, the higher muscle strength seems to superimpose the association with vitamin D. Overall, our results indicate the importance of sufficient levels of vitamin D and offers physical activity perspectives for children with overweight and obesity.
ISRCTN: https://doi.org/10.1186/ISRCTN62310987 .
• Studies have shown a positive association between vitamin D status and handgrip strength in older adults while studies in children and adolescents are scarce. • Conflicting results were found on whether overweight and obesity are associated with reduced or increased handgrip strength compared to normal weight.
• The results of this large pan-European study in children and adolescents indicate that a sufficient vitamin D status is associated with better handgrip strength, particularly in participants with thinness/normal weight. • Children with overweight and obesity have a higher handgrip strength as compared to children with thinness/normal weight which seems to superimpose the positive association between vitamin D status and handgrip strength in this group.
本研究旨在探讨儿童和青少年中维生素D状态与握力之间的关联，并考虑体重状况。纳入了欧洲IDEFICS/I.Family队列中7至<16岁的参与者。在2013/2014年测量了血清25-羟基维生素D[25(OH)D]和握力。在多变量逻辑回归模型中，我们研究了调整人口统计学变量、BMI z评分、体育俱乐部会员资格、屏幕时间和紫外线强度后，维生素D状态与握力之间的关联。维生素D充足的儿童握力高的几率更高（OR = 1.92，95%置信区间：1.12，3.30），但这种关联仅限于体重过轻/正常体重的儿童（OR = 2.60，95%置信区间：1.41 - 4.81）。超重（OR = 2.64，95%置信区间：2.00，3.49）和肥胖（OR = 4.53，95%置信区间：2.93，7.02）的儿童比体重过轻/正常体重的儿童更有可能握力高。
在我们的研究中，维生素D与肌肉力量的正相关仅限于BMI低和正常的儿童。在超重或肥胖的儿童中，较高的肌肉力量似乎叠加了与维生素D的关联。总体而言，我们的结果表明了充足维生素D水平的重要性，并为超重和肥胖儿童提供了体育活动方面的观点。
ISRCTN：https://doi.org/10.1186/ISRCTN62310987 。
• 研究表明，老年人中维生素D状态与握力之间存在正相关，而儿童和青少年中的研究较少。• 与正常体重相比，超重和肥胖与握力降低还是增加存在相互矛盾的结果。
• 这项针对儿童和青少年的大型泛欧洲研究结果表明，充足的维生素D状态与更好的握力相关，特别是在体重过轻/正常体重的参与者中。• 与体重过轻/正常体重的儿童相比，超重和肥胖的儿童握力更高，这似乎叠加了该组中维生素D状态与握力之间的正相关。
